Faculty Information - TAKAGI Riyou

Published papers

Academic conference presentation

Research areas

Education

Rsearch funding number

（Last updated : 2026-01-06 15:32:27）

TAKAGI Riyou
Department Graduate School of Medical Science, Graduate School of Medical Science

Position Assistant Professor

■ Published papers

1.	Case report	Mid-term outcomes of a bio-artificial pleura composed of autologous dermal fibroblasts used to close intraoperative pulmonary air leaks caused by intraoperative pleural injury: A case report. 2025/12
2.	Original article	Continuous adipose-derived stem cell therapy from the neonatal stage effectively reduces Duchenne muscular dystrophy symptoms in rats. 2025/08
3.	Original article	Intravenous mesenchymal stem cell transplantation mitigates pulmonary vascular remodeling but poses dose related risks in a pulmonary veno-occlusive disease model. 2025/05/28
4.	Original article	Allogeneic fibroblast sheets prevent pulmonary air leaks caused by rat pleural defects without adhesion to the thoracic wall. 2025/03
5.	Other	Lessons learned from contamination with endotoxin originated from the supplement in the cell culture medium. 2024/12
6.	Original article	Dual-color FISH analyses of xenogeneic human fibroblast sheets transplanted to repair lung pleural defects in an immunocompromised rat model. 2024/05/15
7.	Original article	Effect of basic fibroblast growth factor with collagen/gelatin fixture in a rabbit model of nasal septum perforation. 2024/03
8.	Original article	Functional and long-lived melanocytes from human pluripotent stem cells with transient ectopic expression of JMJD3. 2023/09
9.	Original article	Evaluation of safety and efficacy of autologous oral mucosa-derived epithelial cell sheet transplantation for prevention of anastomotic restenosis in congenital esophageal atresia and congenital esophageal stenosis. 2023/04
10.	Original article	Long-term outcomes of regenerative treatment by endoscopic oral mucosal epithelial cell sheet transplantation for the prevention of esophageal stricture after endoscopic resection 2023/02
11.	Original article	Laminin-221-derived recombinant fragment facilitates isolation of cultured skeletal myoblasts 2022/05
12.	Original article	A novel alveolar epithelial cell sheet fabricated under feeder-free conditions for potential use in pulmonary regenerative therapy 2022/03
13.	Original article	First-in-human autologous oral mucosal epithelial sheet transplantation to prevent anastomotic re-stenosis in congenital esophageal atresia. 2022/01
14.	Original article	Laminin-511-derived recombinant fragment and Rho kinase inhibitor Y-27632 facilitate serial cultivation of keratinocytes differentiated from human embryonic stem cells. 2021/12
15.	Original article	Restoration of keratinocytic phenotypes in autonomous trisomy-rescued cells. 2021/08
16.	Original article	Development of a nasal mucosa-removal model for evaluating cell therapy. 2021/03
17.	Original article	Bio-artificial pleura using autologous dermal fibroblast sheets to mitigate air leaks during thoracoscopic lung resection. 2021/01/04
18.	Original article	Evaluation of human keratinocyte sheets transplanted onto porcine excised esophagus after submucosal dissection in an ex vivo model 2020/12/10
19.	Other	Bio-artificial pleura using allogenic cell sheet for closing of lung air leakage. 2020/12/01
20.	Original article	A stable protocol for the fabrication of transplantable human oral mucosal epithelial cell sheets for clinical application 2020/06
21.	Original article	Transplantation of autologous oral mucosal epithelial cell sheets inhibits the development of acquired external auditory canal atresia in a rabbit model. 2020/05
22.	Original article	Fabrication of tissue‐engineered cell sheets by automated cell culture equipment 2019/12
23.	Original article	Explant culture of oral mucosal epithelial cells for fabricating transplantable epithelial cell sheet. 2019/06
24.	Original article	Off-the-Shelf Cell Sheets as a Pleural Substitute for Closing Visceral Pleural Injuries. 2019/04
25.	Original article	In vivo periodontium formation around titanium implants using periodontal ligament cell sheet 2018/08
26.	Original article	Oral epithelial cell sheets engraftment for esophageal strictures after endoscopic submucosal dissection of squamous cell carcinoma and airplane transportation. 2017/12
27.	Original article	Bio-artificial pleura using an autologous dermal fibroblast sheet 2017/10
28.	Original article	Establishment of production method of small intestinal epithelial cell sheets under two-dimensional cell culture 2017/03
29.	Original article	Middle ear mucosal regeneration by tissue-engineered cell sheet transplantation 2017/03
30.	Original article	Transplantation of tissue-engineered cell sheets for stricture prevention after endoscopic submucosal dissection of the oesophagus. 2016/12
31.	Original article	Brush biopsy of human oral mucosal epithelial cells as a quality control of the cell source for fabrication of transplantable epithelial cell sheets for regenerative medicine 2016/06
32.	Original article	Transplantation of tissue-engineered cell sheets for stricture prevention after endoscopic submucosal dissection of the oesophagus 2016/02
33.	Original article	Allogeneic Transplantation of Periodontal Ligament-Derived Multipotent Mesenchymal Stromal Cell Sheets in Canine Critical-Size Supra-Alveolar Periodontal Defect Model. 2016/01
34.	Original article	Membrane-Permeable Calpain Inhibitors Promote Rat Oral Mucosal Epithelial Cell Proliferation by Inhibiting IL-1α Signaling. 2015/07
35.	Other	Fabrication of transplantable corneal epithelial and oral mucosal epithelial cell sheets using a novel temperature-responsive closed culture device. 2015/05
36.	Original article	How to prevent contamination with Candida albicans during the fabrication of transplantable oral mucosal epithelial cell sheets 2015/02
37.	Original article	The effect of transplantation of nasal mucosal epithelial cell sheets after middle ear surgery in a rabbit model. 2015/02
38.	Review article	Application of regenerative medical technology using tissue-engineered cell sheets for endoscopic submucosal dissection of esophageal neoplasms 2015/01
39.	Review article	Prevention of esophageal strictures after endoscopic submucosal dissection 2014/11
40.	Original article	Significantly different proliferative potential of oral mucosal epithelial cells between six animal species. 2014/06
41.	Original article	The regulation of epithelial cell proliferation and growth by IL-1 receptor antagonist 2013/01
42.	Original article	Profiling of extracellular matrix and cadherin family gene expression in mouse feeder layer cells: type VI collagen is a candidate molecule inducing the colony formation of epithelial cells. 2012/12
43.	Original article	Punch and spindle-shaped biopsies for collecting oral mucosal tissue for the fabrication of transplantable autologous epithelial cell sheets 2012/10
44.	Original article	Prevention of Esophageal Stricture After Endoscopic Submucosal Dissection Using Tissue-Engineered Cell Sheets 2012/09
45.	Other	A tissue-engineered fibroblast sheet as a pleural substitute for chest surgery. 2012
46.	Original article	Fabrication and validation of autologous human oral mucosal epithelial cell sheets to prevent stenosis after esophageal endoscopic submucosal dissection 2011/11
47.	Original article	Comparison of different tissue-derived stem cell sheets for periodontal regeneration in a canine 1-wall defect model. 2011/09
48.	Original article	Low calcium culture condition induces mesenchymal cell-like phenotype in normal human epidermal keratinocytes 2011/07
49.	Original article	Preparation of keratinocyte culture medium for the clinical applications of regenerative medicine 2011/04
50.	Other	Fabrication of human oral mucosal epithelial cell sheets for treatment of esophageal ulceration by endoscopic submucosal dissection 2010/12
51.	Original article	A novel method of culturing human oral mucosal epithelial cell sheet using post-mitotic human dermal fibroblast feeder cells and modified keratinocyte culture medium for ocular surface reconstruction. 2010/09
52.	Other	Temporary inhalation anesthesia in experimental pigs 2010/01
53.	Original article	Periodontal regeneration with multi-layered periodontal ligament-derived cell sheets in a canine model 2009/05
54.	Original article	Functional closure of visceral pleural defects by autologous tissue engineered cell sheets. 2008/10
55.	Original article	Cementum-periodontal ligament complex regeneration using the cell sheet technique. 2008/06
56.	Review article	Grand Espoir: Robotics in Regenerative Medicine 2007/10
57.	Original article	The effect of micropores in the surface of temperature-responsive culture inserts on the fabrication of transplantable canine oral mucosal epithelial 2006/11
58.	Original article	Fabrication of transplantable human oral mucosal epithelial cell sheets using temperature-responsive culture inserts without feeder layer cells 2006/09
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■ Academic conference presentation

1.	Long-term follow-up results of cell sheet transplantation for pulmonary air leaks （口頭，一般） 2019/10/31
2.	Laminin-521 maintains proliferation activity of cultured human stratified squamous epithelial cells with less effect of individual difference. （口頭，一般） 2016/06/24
3.	Long-Term Outcomes of Endoscopic Transplantation of Oral Mucosul Epithelial Cell Sheets to Prevent Esophaeal Stricture after Endoscopic Submucosal Dissection （口頭，一般） 2015/09/08
4.	The study of long term outcomes utilizing tissue-engineered cell sheet transplantetipn for the prevention of oesophageal stricture （ポスター掲示，一般） 2014/10/18
5.	Contractile Manipulation of Epithelial Cell Sheets with Serum by Regulating Myosin Phosphorylation and Actomyosin Dynamics （口頭，一般） 2013/10/26
6.	Western Blot Analysis of Keratin Expressions in Human Oral Mucosal Epithelial Cells Collected by Brush Biopsy （ポスター掲示，一般） 2013/10/26
7.	Biopsies for collecting oral mucosal tissue for tissue-engineered cell sheets （ポスター掲示，一般） 2012/09/11
8.	Periodontal regeneration with autologous periodontal ligament-derived cell sheets in clinical settings （ポスター掲示，一般） 2012/09/08
9.	Transplantation of fabricated autologous epidermal cell sheets for prevention of esophageal stricture after full-circumferential endoscopic submucosal dissection (ESD) in a swine model （ポスター掲示，一般） 2012/09/06
10.	Transplantation of autologous human oral mucosal epithelial cell sheets for seophageal endoscopic resection （ポスター掲示，一般） 2012/09/05
11.	transplantation of human fibroblast cell sheets for colorectal endoscopic submucosal dissection ina xenogeneic model,an animal feasibillity study （ポスター掲示，一般） 2012/09/05
12.	Retinoic Acid Controls Cultured and Harvested Epithelial Cell Sheet's Shrinkage via the Regulation of Actomyosin Contraction （ポスター掲示，一般） 2011/12/03
13.	IL-1 Receptor Antagonist Promotes the Proliferation of Stratified Squamous Epithelial Cells （ポスター掲示，一般） 2011/11/09
14.	Transplantation of cultured autologous epidermal cell sheets for prevention of esophageal stricture after full-circumferential endoscopic submucosal dissection (ESD) in a swine model （口頭，一般） 2011/10/25
15.	Prevantion of postoperative atricture after esophageal endoscopic submucosal dissection by transplantation of autologous human oral mucosal epithelial cell sheets （口頭，一般） 2011/10/22
16.	Transplantation of cultured autologous epidermal cell sheets for prevention of esophageal stricture after full-circumferental endoscopic submucosal dissection (ESD) in a swine model （口頭，一般） 2011/10/22
17.	Periodontal Regenration With Periodontal Ligament-Derived Cell Sheets: A Translational Research For The Clinical Trial. （口頭，シンポジウム・ワークショップパネル（その他）） 2010/09/17
18.	Off-the-shelf cell sheets for closure of visceral pleural injuries （一般） 2009/09/01
19.	Periodontal regeneration with multi-layered periodontal ligament cell sheets （口頭，一般） 2009/04/03
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■ Research areas

Cell biology, Dermatology (Key Word：keratinocyte, regenerative medicine)

■ Education

1.		Graduate School of Medical Science, Tokyo Women's Medical University, Ph.D.
2.	2001/04～2003/03	〔Master degree program〕〔Master Course〕 Department of Biomolecular Science, Faculty of Science, Toho University, Completed, Master of Science

■ Rsearch funding number

10723091