Faculty Information - HIGUCHI Tomoaki

（Last updated : 2025-03-03 12:01:10）

HIGUCHI Tomoaki
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Department of Internal Medicine, Division of Rheumatology

Position Endowed Assistant Professor

■ Published papers

1.	Case report	A case of gastric/duodenal diffuse large B cell lymphoma observed during the administration of tacrolimus/azathioprine for dermatomyositis 2025/02
2.	Original article	Association of elevated serum carbohydrate antigen 19-9 levels with extensive interstitial lung disease in patients with systemic sclerosis: A cross-sectional study 2023/11/20
3.	Original article	Antifibrotic effect of apremilast in systemic sclerosis dermal fibroblasts and bleomycin-induced mouse model 2023/11/08
4.	Original article	Evaluation of RABBIT risk score in Japanese patients with rheumatoid arthritis starting first bDMARDs: a validation study using the IORRA cohort data. 2023/07/06
5.	Original article	Evaluation of Ministry of Health, Labour and Welfare diagnostic criteria for antineutrophil cytoplasmic antibody-associated vasculitis compared to ACR/EULAR 2022 classification criteria. 2023/06/03
6.	Case report	A case of systemic lupus erythematosus having concurrent Evans syndrome and acquired thrombotic thrombocytopenic purpura. 2023/02/08
7.	Original article	Validation of new ACR/EULAR 2022 classification criteria for anti-neutrophil cytoplasmic antibody-associated vasculitis. 2023/01/27
8.	Case report	A case of Takayasu arteritis complicated with acute pericarditis at initial presentation. 2023/01/03
9.	Original article	Systematic review and meta-analysis for 2023 clinical practice guidelines of the Japan research committee of the ministry of health, labour, and welfare for intractable vasculitis for the management of ANCA-associated vasculitis. 2022/09/16
10.	Original article	Impact of concomitant chronic kidney disease on hospitalised infections and remission in patients with rheumatoid arthritis: results from the IORRA cohort. 2022/08/20
11.	Original article	Characteristics of Japanese patients with systemic sclerosis complicated with calcinosis. 2021/04/28
12.	Original article	Single nucleotide polymorphisms of the HIF1A gene are associated with susceptibility to pulmonary arterial hypertension in systemic sclerosis and contribute to SSc-PAH disease severity. 2020/03/06
13.	Original article	Antifibrotic effects of 2-carba cyclic phosphatidic acid (2ccPA) in systemic sclerosis: contribution to the novel treatment 2019/04
14.	Original article	Capillary abnormalities observed by nailfold video-capillaroscopy in Japanese patients with systemic sclerosis. 2018/11/01
15.	Original article	Flagellar filament structural protein induces Sjögren's syndrome-like sialadenitis in mice. 2017/07
16.	Original article	Sildenafil attenuates the fibrotic phenotype of skin fibroblasts in patients with systemic sclerosis. 2015/12
17.	Original article	Identification of commensal flora-associated antigen as a pathogenetic factor of autoimmune pancreatitis 2014/03
18.	Original article	Ghrelin attenuates collagen production in lesional fibroblasts from patients with systemic sclerosis 2013/05
19.	Case report	A case of ulcerative colitis complicating anti-tumor necrosis factor treatment for rheumatoid arthritis: successful treatment with leukocytapheresis. 2013/02
20.	Case report	The usefulness of 3D-CT angiography in polyarteritis nodosa. 2012
21.	Case report	A case of multicentric Castleman's disease having lung lesion successfully treated with humanized anti-interleukin-6 receptor antibody, tocilizumab. 2010/09
22.	Original article	Negative correlation of anti-U1RNP antibody titers and the amount of salivary secretion with age correction. 2008
23.	Original article	The relationships between titers of anti-Ro or anti-La as measured by ELISA and salivary production rate with age correction. 2008
24.	Original article	Primary biliary cirrhosis in female subjects with sicca-associated antibodies. 2007
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■ Academic conference presentation

1.	Causes and risk factors for death in Japanese systemic sclerosis 2024/03/14
2.	Autoimmunity(FOXM1 regulates fibrotic activity of skin fibroblasts derived from patients with systemic sclerosis) 2022/11
3.	Association study of IFIH1 gene polymorphisms in systemic sclerosis (SSc) 2022/04/25
4.	MPO-ANCA POSITIVITY IS RELATED TO INTERSTITIAL LUNG DISEASE IN SYSTEMIC SCLEROSIS 2018/06/15
5.	Apremilast Attenuates the Fibrogenic Phenotype of Dermal Fibroblasts from Patients with Systemic Sclerosis, Contributing to the Prevention of the Progression of Experimental Dermal Fibrosis 2016/11/16
6.	ASSOCIATION OF THE HYPOXIA-INDUCIBLE FACTOR 1A (HIF1ALPHA) GENE POLYMORPHISM IN JAPANESE SYSTEMIC SCLEROSIS (SSC) WITH THE PULMONARY ARTERIAL HYPERTENSION (PAH) 2016/02/19
7.	ASSOCIATION OF THE HYPOXIA-INDUCIBLE FACTOR 1A (HIF1ALPHA) GENE POLYMORPHISM IN JAPANESE SYSTEMIC SCLEROSIS (SSC) WITH THE PULMONARY ARTERIAL HYPERTENSION (PAH) 2015/06/13
8.	EARLY DETECTION AND TREATMENT FOR BORDERLINE PULMONARY ARTERIAL HYPERTENSION IN PATIENTS WITH SYSTEMIC SCLEROSIS IN JAPAN 2015/06/13
9.	CCPA REVERSES THE FIBROTIC PHENOTYPE OF DERMAL FIBROBLASTS IN SYSTEMIC SCLEROSIS 2015/06/12
10.	Association of BTB and CNS homology 2 (BACH2) gene polymorphism with systemic sclerosis (SSc) in Japanese population. 2015/04/25
11.	Commensal flora would be silently involved in the pathogenesis of autoimmune pancreatitis and associated diseases 2015/04/24
12.	Could microorganisms-originated adjuvant be a triggering factor of IgG-related disease? 2015/04/24
13.	Possible involvement of FliC from Escherichi coli as a pathogenic factor of IgG4-related disease 2014/12/12
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■ Education

2013/04～2017/03

〔Doctoral course〕, Graduate School, Division of Medicine, Tokyo Women's Medical University, Completed,