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 八千代医療センター　小児科
Summary Research grants & projects Published papers
Books Academic conference presentation


Professor：

    Takanashi Jiyun'ichi
   Hamada Hiromichi 		Assistant Professor：
    Anbe Masahiro
   Kimura Shiyou
   Shinozaki Keisuke
   Shimoyama Kiyouhei
   Sugiura Kenta
   Hara Mayumi
   Hirose Shiyouko
■ Summary
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■ Research grants & projects
1.    (Grant No.：19K08237)
 Budget amount：\700,000  (Principal investigator)
2.    (Grant No.：H30-難治等（難）-一般-007)
 Budget amount：\300,000  (Co-investigator)
3.    (Grant No.：H30-難治等(難)-一般-008)
 Budget amount：\600,000  (Co-investigator)
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■ Research works
Journal Book Presentation Other presentations
JapaneseEnglish JapaneseEnglish Domesticinternational
First authorCorresponding
Author		Co-authorFirst authorCorresponding
Author		Co-author First authorCo-authorFirst authorCo-author PresenterCo-presenterPresenterCo-presenter PresenterCo-presenter
 5 5 2 2 3 9  0 1 0 0  2 5  0 1  1 0
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■ Published papers
Original article
1. Mizuguchi M, Ichiyama T, Imataka G, Okumura A, Goto T, Sakuma H, Takanashi J, Murayama K, Yamagata T, Yamanouchi H, Fukuda T, Maegaki Y.：  Guidelines for the diagnosis and treatment of acute encephalopathy in childhood.  Brain & Development  43 (1) ：2-31 , 2021.1   DOI:10.1016/j.braindev.2020.08.001
2. Kashii H, Ueno H, Li H, Tsurusaki Y, Ikeda C, Kurata H, Okada T, Shimazu T, Imamura H, Enomoto Y, Takanashi J, Kurosawa K, Inoue K：  POLR1C variants dysregulate splicing and cause hypomyelinating leukodystrophy.  Neurology. Genetics.  6 (6) ：e524 , 2020.10   DOI:doi.org/10.1212/NXG.0000000000000524
3. Kasai M, Shibata A, Hoshino A, Maegaki Y, Yamanouchi H, Takanashi J, Yamagata T, Sakuma H, Okumura A, Nagase H, Ishii A, Goto T, Oka A, Mizuguchi M：  Epidemiological changes of acute encephalopathy in Japan based on national surveillance for 2014-2017.  Brain & Development  42 (7) ：508-514 , 2020.8   DOI:https://doi.org/10.1016/j.braindev.2020.04.006
4. Itai T, Miyatake S, Taguri M, Nozaki F, Ohta M, Osaka H, Morimoto M, Tandou T, Nohara F, Takami Y, Yoshioka F, Shimokawa S, Okuno-Yuguchi J, Motobayashi M, Takei Y, Fukuyama T, Kumada S, Miyata Y, Ogawa C, Maki Y, Togashi N, Ishikura T, Kinoshita M, Mitani Y, Kanemura Y, Omi T, Ando N, Hattori A, Saito S, Kitai Y, Hirai T, Arai H, Ishida F, Nabatame S, Smigiel R, Kato M, Tanda K, Saito Y, Ishiyama A, Noguchi Y, Miura M, Nakano T, Hirano K, Honda R, Kuki I, Takanashi J, Takauchi A, Fukusawa T, Seiwa C, Harada A, Yachi Y, Higashiyama H, Terashima H, Kumagai T, Hada S, Abe Y, Miyagi E, Uchiyama Y, Fujita A, Imagawa E, Azuma Y, Hamanaka K, Koshimizu E, Mitsuhashi S, Mizuguchi T, Takata A, Miyake N, Tsurusaki Y, Doi H, Nakashima M, Saitsu H, Matsumoto N：  Prenatal clinical manifestations in individuals with COL4A1/2 variants.  Journal of Medical Genetics  in press ：1 , 2020.8   DOI:10.1136/jmedgenet-2020-106896
5. Kobayashi T, Ayusawa M, Suzuki H, Abe J, Ito S, Kato T, Kamada M, Shiono J, Suda, K, Tsuchiya K, Nakamura T, Nakamura Y, Nomura Y, Hamada H, Fukazawa R, Furuno K, Matsuura H, Matsubara T, Miura M, Takahashi K.：  Revision of diagnostic guidelines for Kawasaki disease (6th revised edition).  Pediatric International  00 (00) ：00-00 , 2020.5
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Review article
1. 髙梨潤一†：  けいれん重積型（二相性）急性脳症 up-to -date.  日本小児科学会雑誌  125 (1) ：1-10 , 2021.1
2. 髙梨潤一†：  急性脳症の今昔.  東京小児科医会報  39 (1) ：77-81 , 2020.8
3. 髙梨潤一†*：  脳形成障害の最前線. III. 脳幹小脳形成異常の画像診断.  脳と発達  52 (3) ：158-160 , 2020.5
4. 髙梨潤一†*：  MRスペクトルスコピー (MRS: magnetic resonance spectroscopy).  小児内科  52 (4) ：541-546 , 2020.4
Case report
1. Nozomu Oshima, Hiromichi Hamada, Shoko Hirose, Kyohei Shimoyama, Makoto Fujimori,
Takafumi Honda, Kumi Yasukawa, Naruhiko Ishiwada, Misako Ohkusu, Jun-ichi Takanashi：  Panton-Valentine leukocidin-positive novel sequence type 5959 community-acquired methicillin-resistant Staphylococcus aureus meningitis complicated by cerebral infarction in a 1-month-old infant.  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy  27 (1) ：103-106 , 2021.1   DOI:10.1016/j.jiac.2020.09.011
2. Asaki Y†, Murofushi Y, Yasukawa K, Hara M, Takanashi J*：  Neurochemistry of Hyponatremic Encephalopathy Evaluated by MR Spectroscopy.  Brain & Development  42 ：767-770 , 2020.9   DOI:https://doi.org/10.1016/j.braindev.2020.07.005
3. NISHIKAWA Aiko†, OTNI Yui, ITO Susumu, NAGATA Satoru, SHIOTA Mutsuki, TAKANASHI Jun-ichi, NAKASHIMA Mitsuko, SAITSU Hirotomo, MATSUMOTO Naomichi, OGUNI Hirokazu*：  A de novo GABRB2 variant associated with myoclonic status epilepticus and rhythmic high-amplitude delta with superimposed (poly) spikes (RHADS).  Epileptic Disorders:  22 (4) ：476-481 , 2020.8   DOI:10.1684/epd.2020.1183
4. 山本陽子†, 平澤恭子*, 今井 憲, 佐藤友哉, 戸津五月, 和田雅樹, 髙梨潤一, 永田 智：  出生直後からblepharoclonusを認めた脳幹小脳形成異常.  日本小児科学会雑誌  124 (6) ：995-1001 , 2020.6
5. Hiroyuki FUJII, Noriko SATO, Junichi TAKANASHI, Yukio KIMURA, Emiko MORIMOTO, Yoko SHIGEMOTO, Fumio SUZUKI, Masayuki SASAKI, and Hideharu SUGIMOTO：  Altered MR imaging findings in a Japanese female child with PRUNE1-related disorder.  Brain & Development  42 ：302-306 , 2020   DOI:10.1016/j.braindev.2019.12.001
Other
1. 髙梨潤一†：  遠く及ばざれど.  脳と発達  53 (1) ：2 , 2021.1
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■ Books
1. 髙梨潤一：  急性脳症.  今日の小児治療指針　第17版  662-664.  医学書院,  東京, 2020.11
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■ Academic conference presentation
1. Nanako Takase, Kentaro Sano, Keito Saito, Junichi Takanashi： Age-related changes in glutamate and glutamine concentrations observed on MR spectroscopy.  2020 International Symposium on the Pathophysiology of Developmental and Epileptic Encephalopathy,  Okayama, Japan (WEB),  2020/06
2. 髙梨潤一： 「小児特有の外傷性脳障害;Infantile traumatic brain injury with a biphasic clinical course and late reduced diffusion (TBIRD) と Traumatic white matter lacerations in children (TWLC).  第5回小児頭部損傷研究会,  WEB,  2021/03
3. 佐野賢太郎, 岡田朋子, 安河内悠, 髙瀨菜々子, 塩田惠, 白戸由理, 安川久美, 佐久間啓、髙梨潤一： 薬剤抵抗性の焦点起始発作で発症した抗NMDA受容体脳炎の２歳男児例.  第７４回日本小児神経学会関東地方会,  東京,  2021/03
4. ◎坂田裕香, 岡田朋子, 佐野賢太郎, 安部昌宏, 下山恭平, 濱田洋通, 髙梨潤一： 急性胃腸炎・脱水症の診断で治療開始後、診断に至った運動後急性腎不全の一例.  第218回日本小児科学会千葉地方会,  千葉,  2021/02
5. ◎上條健介、原真由美, 淺木弓英, 廣瀬翔子, 本田隆文, 幸地克憲, 濱田洋通, 髙梨潤一： 繰り返す Breif unexplained event (BRUE) から小駆動凶作の診断に至った乳児の１例.  第218回日本小児科学会千葉地方会,  千葉市（WEB）,  2021/02
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  ＊：Corresponding Author
 †：First Author
◎：Presenter