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Department of Pharmacology
Professor：
Maru Yoshirou
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Assistant Professor：
Tsukahara Fujiko
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Assistant Professor：
須藤 遥
Tomita Takeshi
HIRATSUKA Sachie
増田 潤子
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■ Summary
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■ Research grants & projects
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1.
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Budget amount：\5,000,000 (Principal investigator)
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2.
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(Grant No.：21790330)
Budget amount：\2,210,000 (Principal investigator)
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3.
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(Grant No.：21117008)
Budget amount：\2,550,000 (Principal investigator)
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■ Research works
| Journal |
Book |
Presentation |
Other presentations |
| Japanese | English |
Japanese | English |
Domestic | international |
| First author | Corresponding
Author | Co-author | First author | Corresponding
Author | Co-author |
First author | Co-author | First author | Co-author |
Presenter | Co-presenter | Presenter | Co-presenter |
Presenter | Co-presenter |
| 0 | 0 | 0 | 0 | 1 | 9 |
0 | 3 | 0 | 0 |
1 | 5 |
0 | 5 |
0 | 0 |
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■ Published papers
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Original article
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1.
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Saegusa J, Yamaji S, Ieguchi K, Wu CY, Lam KS, Liu FT, Takada YK, Takada Y.：
The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling.
Journal of Biological Chemistry
284
(36)
：24106-24116
, 2009.9
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2.
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Hirata Michiko†, Matsumoto Chiho, Takita Morichika, Miyaura Chisato*, Inada Masaki：
Naringin suppresses, osteoclast formation and enhances bone mass in mice.
Journal of Health Science
55
(3)
：463-467
, 2009.6
DOI:http://doi.org/10.1248/jhs.55.463
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3.
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TOMITA T.†, Yamada A., Miyakoshi M., Kido T., Sheikh F., Scrisodsai A., Miyajima A., Donnelly R. P., and Kimura S*：
Oncostatin M regulates secretoglobin 3A1 and 3A2 expression in a bidirectional manner.
American journal of physiology. Lung cellular and molecular physiology
(40)
：620-630
, 2009
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4.
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Miyoshi H†, Deguchi A, Nakau M, Kojima Y, Mori A, Oshima M, Aoki M, Taketo MM*：
Hepatocellular carcinoma development by conditional beta-catenin activation in Lkb1(+/-) mice.
Cancer Science
100
：2046-2053
, 2009
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5.
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Yamazaki T†, Masuda J, Omori T, Usui R, Akiyama H, Maru Y*.：
EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility.
Journal of cell science
122
：243-255
, 2009
DOI:10.1242/jcs.036467
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Review article
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1.
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Maru Yoshiro：
A Concept of Homeostatic Inflammation Provided by Endogenous TLR4 Agonists that Function Before and After Danger Signal for Metastasis.
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
8
(4)
：337-347
, 2009
DOI:10.2174/187152309789839064
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2.
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Maru Yoshiro：
A Concept of Homeostatic Inflammation Provided by Endogenous TLR4 Agonists that Function Before and After Danger Signal for Metastasis.
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
8
：337-347
, 2009
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3.
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Maru Yoshiro：
Logical structures extracted from metastasis experiments.
Cancer Sci
100
：2006-2013
, 2009
DOI:10.1111/j.1349-7006.2009.01300.x
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4.
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Maru Y.：
The tumor suppressor LZTS2 functions through the cellular samurai Katanin.
Central European journal of biology.
4
：1-10
, 2009
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Other
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1.
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Maru Y.：
Activation of TLR4 in pre-metastatic phase: crosstalk with TNF.
Proc. 12th international TNF conference (April, 2009, Madrid)
：n/a
, 2009.4
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■ Books
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1.
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丸義朗：
〈抄録〉第30回 日本臨床薬理学会年会
2009年12月3〜5日横浜シンポジウム3：GSK-3シグナル伝達経路を標的とする治療薬・診断法の開発.
臨床薬理
17S-18S.
Jpn JClin Pharmacol Ther,
横浜, 日本,
2010.3
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2.
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丸義朗：
「転移とは何か」.
細胞工学
1.
秀潤社,
東京，日本,
2009
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3.
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丸義朗：
癌転移における白血球の役割.
実験医学
107-112.
羊土社,
東京，日本,
2009
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■ Academic conference presentation
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1.
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◎Tomita T., Maru Y.：
Organ Specific Resident Cells Determine Organotropism in Metastasis.
Eighth Joint Conference of The American Association For Cancer Research and The Japanese Cancer Association,
Waikoloa, Hawaii, USA,
2010/02
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2.
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◎Maru Y：
The endogenous TLR4 ligands regulate pre-metastatic soil.
The 8th Japan-China Joint Conference for Cancer Research,
Osaka, Japan,
2009/10
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3.
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◎Maru Y：
The endogenous TLR4 ligands regulate pre-metastatic soil.
2nd International Kloster Seeon Meeting "Cellular and Molecular Mechanisms of Tumor Progression and Metastasis",
Kloster Seeon, Germany,
2009/09
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4.
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◎Maru Y：
Strategies to cope with drug resistance in taxanes and imatinib.
Japanese-German Cancer Workshop,
Hamburg, Germany,
2009/09
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5.
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◎Maru Y：
How organ-specific pre-metastatic soil is prepared.
9th ESH conference on angiogenesis,
Helsinki, Finland,
2009/06
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6.
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塚原富士子, 丸義朗：
Regulation of stabilization and degradation of chronic myelogenous leukemia oncoprotein, BCR-ABL by molecular chaperone.
第８３回日本薬理学会年会,
大阪,
2010/03
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7.
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◎丸義朗：
Crosstalk between TNFR and TLR ワークショップ「炎症と癌を繋ぐ転写因子NF-kB研究の最先端」.
第32回日本分子生物学会年会,
横浜，日本,
2009/12
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8.
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Tomita Takeshi, Maru Yoshiro：
Role of Clara Cells in Lung-specific Metastasis.
68th Annual Meeting of The Japanese Cancer Association,
Yokohama, Japan,
2009/10
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9.
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塚原富士子, 丸義朗：
Bidirectional signaling between c-Cbl and chronic myelogenous leukemia oncoprotein, BCR-ABL.
68th Annual Meeting of the Japanese Cancer Association,
横浜,
2009/10
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10.
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◎丸義郎：
臓器特異的転移前土壌の形成 シンポジウム「病理解析に基づいた多段階発がんの分子基盤の解明」.
第68回日本癌学会学術総会,
横浜，日本,
2009/10
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11.
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丸義朗：
転移前土壌と自然炎症 シンポジウム「自然炎症—病原体センサーと内因性リガンドによる非感染性炎症反応の分子基盤」.
第82回日本生化学会大会,
神戸, 日本,
2009/10
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