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 八千代医療センター 病理診断科
Summary Research grants & projects Published papers
Books Academic conference presentation


Professor:

   HIROSHIMA Kenzo
Associate Professor:
   増永 敦子
Assistant Professor:
   Oide Takashi
■ Summary
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■ Research grants & projects
1.  
 Budget amount:\5,400,000  (Principal investigator)
2.  
 Budget amount:\5,000,000  (Co-investigator)
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■ Research works
Journal Book Presentation Other presentations
JapaneseEnglish JapaneseEnglish Domesticinternational
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 4 3 5 8 8 13  0 4 0 1  12 12  4 12  1 1
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■ Published papers
Original article
1. Guntulu Ak, Yuji Tada, Hideaki Shimada, Selma Metintas, Masaaki Ito, Kenzo Hiroshima,
Masatoshi Tagawa*, Muzaffer Metintas*:  Midkine is a potential novel marker for malignant mesothelioma with different prognostic and diagnostic values from mesothelin.  BMC cancer  17 :212 , 2017.3   DOI:10.1186/s12885-017-3209-5
2. Shoutaro Tsuji, Kota Washimi, Taihei Kageyama, Makiko Yamashita, Mitsuyo Yoshihara, Rieko Matsuura, Tomoyuki Yokose, Yoichi Kameda, Hiroyuki Hayashi, Takao Morohoshi, Yukio Tsuura, Toshikazu Yusa, Takashi Sato, Akira Togayachi, Hisashi Narimatsu, Toshinori Nagasaki, Kotaro Nakamoto, Yasuhiro Moriwaki, Hidemi Misawa, Kenzo Hiroshima, Yohei Miyagi, Kohzoh Imai1:  HEG1 is a novel mucin-like membrane protein that serves as a diagnostic and therapeutic target for malignant mesothelioma.  Scientific Reports  7 :45768 , 2017.3   DOI:10.1038/srep45768
3. Di Wu, Kenzo Hiroshima*, Toshikazu Yusa, Daisuke Ozaki, eitetsu koh, Yasuo Sekine, Shinji Matsumoto, Kazuki Nabeshima, Ayuko Sato, Tohru Tsujimura, Hisami Yamakawa, Yuji Tada, Hideaki Shimada, Masatoshi Tagawa:  Usefulness of p16/CDKN2A FISH and BAP1 Immunohistochemistry for the Diagnosis of Biphasic Mesothelioma.  Annals of diagnostic pathology  26 :31-37 , 2017.2   DOI:10.1016/j.anndiagpath.
4. Nakano Masayuki*, Ariizumi Shunichi, Yamamoto Masakazu:  Intrahepatic cholangiocarcinoma.  Seminars in diagnostic pathology  34 (2) :160-166 , 2017.2   DOI:10.1053/j.semdp.2016.12.012.
5. Thunnissen E, Borczuk AC, Flieder DB, Witte B, Beasley MB, Chung JH, Dacic S, Lantuejoul S, Russell PA, den Bakker M, Botling J, Brambilla E, de Cuba E, Geisinger K, Hiroshima K, Marchevsky A, Minami Y, Moreira A, Nicholson AG, Yoshida A, Tsao MS, Warth A, Duhig E, Chen G, Matsuno Y, Travis WD, Butnor K, Cooper W, Mino-Kenudson M, Motoi N, Poleri C, Pelosi G, Kerr K, Aisner SC, Ishikawa Y, Buettner RH, Keino N, Yatabe Y, Noguchi M.:  The use of Immunohistochemistry Improves the Diagnosis of Small Cell Lung Cancer and its Differential Diagnosis. An international reproducibility study in a demanding set of cases.  Journal of Thoracic Oncology  12 (2) :334-346 , 2016.12   DOI:10.1016/j.jtho.2016.12.004
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Review article
1. 中野雅行*:  【肝臓I:肝病理診断のポイント-びまん性肝疾患-】 急性肝炎と慢性肝炎の病理学的鑑別.  病理と臨床  35 (5) :214-217 , 2017.3
2. 佐藤之俊, 廣島健三, 伊豫田明, 薄田勝男, 大林千穂, 河原邦光, 斎藤泰紀, 佐藤雅美, 武島幸男, 蔦幸治, 羽場礼次, 三浦弘之, 吉澤明彦, 宝来威, 遠藤千顕, 柿沼廣邦, 竹中明美, 三宅真司.:  細胞診.  日本肺癌学会編. 臨床・病理 肺癌取扱い規約 第8版  :125-148 , 2017.1
3. 大林千穂, 谷田部恭, 武島幸男, 蔦幸治, 鍋島一樹, 仁木利郎, 野口雅之, 東山聖彦, 松野吉宏, 元井紀子, 吉澤明彦, 石川雄一, 石井源一郎, 岡本賢三, 河原邦光, 酒井康裕, 佐藤之俊, 田口健一, 中谷行雄, 林雄一郎, 廣島健三, 南優子.:  病理診断.  日本肺癌学会編. 臨床・病理 肺癌取扱い規約 第8版  :67-124 , 2017.1
4. 廣島健三*:  悪性中皮腫の病理診断.  日本婦人科病理学  7 (2) :35-37 , 2016.11
5. 廣島健三*:  悪性中皮腫の病理診断.  病理と臨床  34 (4) :356-362 , 2016.4
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Case report
1. Oide T*, Hiroshima K, Takahashi Y, Fugo K, Yamatoji M, Kasamatsu A, Endo-Sakamoto Y, Shiiba M, Uzawa K, Tanzawa H, Nagao T, Nakatani Y:  Mucoepidermoid carcinoma with extensive spindled morphology and melanocytic marker expression.  Human pathology  * :* , 2017.3
2. Takahide Toyoda, Atsuko Masunaga, Mitsutoshi Shiba, Kenzo Hiroshima*:  An atypical type A thymoma with lung invasion and pleural metastasis: A case report.  Human pathology  3 :46-50 , 2017.3
3. Oide T*, Hiroshima K, Shibuya K, Nakatani Y:  Primary pulmonary meningioma presenting as a coin lesion.  Internal Medicine  * :* , 2017.3
4. Oide T, Kan M, Masunaga A, Nishino T, Hiroshima K:  Histopathology of immature (ongoing) squamous metaplasia of the stomach.  Pathology International  * :* , 2017.2   DOI:10.1111/pin.12636
5. Yokohori N, Sato A, Hasegawa M, Katsura H, Hiroshima K, Takemura T.:  Effectiveness of Combined Therapy with Pirfenidone and Erythromycin for Unclassifiable Interstitial Pneumonia Induced by HTLV-1-associated Bronchioloalveolar Disorder (HABA).  Internal Medicine  56 (1) :73-78 , 2017.1   DOI:10.2169/internalmedicine
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■ Books
1. 石井源一郎、石川雄一、岡本賢三、河原邦光、酒井康裕、坂下信悟、蔦幸治、武島幸男、田口健一、中谷行雄、鍋島一樹、仁木利郎、二宮浩範、野口雅之、畑中豊、羽場礼次、林雄一郎、廣島健三、福岡順也、松野吉宏、元井紀子、吉澤明彦:    肺癌におけるALK免疫染色 プラクティカルガイド  1-14.  日本肺癌学会・日本病理学会,  東京, 2017.2 Link
2. 佐藤之俊, 廣島健三, 伊豫田明, 薄田勝男, 大林千穂, 河原邦光, 斎藤泰紀, 佐藤雅美, 武島幸男, 蔦幸治, 羽場礼次, 三浦弘之, 吉澤明彦, 宝来威, 遠藤千顕, 柿沼廣邦, 竹中明美, 三宅真司:  細胞診.  臨床・病理 肺癌取扱い規約 第8版  125-148.  金原出版,  東京, 2017.1
3. 大林千穂, 谷田部恭, 武島幸男, 蔦幸治, 鍋島一樹, 仁木利郎, 野口雅之, 東山聖彦, 松野吉宏, 元井紀子, 吉澤明彦, 石川雄一, 石井源一郎, 岡本賢三, 河原邦光, 酒井康裕, 佐藤之俊, 田口健一, 中谷行雄, 林雄一郎, 廣島健三, 南優子:  病理診断.  日本肺癌学会編. 臨床・病理 肺癌取扱い規約 第8版  67-124.  金原出版,  東京, 2017.1
4. 中野孝司, 青江啓介, 石川雄一, 木村智樹, 玄馬顕一, 関戸好孝, 副島俊典, 高橋和久, 田中文啓, 辻村亨, 永安武, 中山優子, 長谷川誠紀, 東山聖彦, 廣島健三, 松本勲, 宮田義浩, 横井香平:  悪性胸膜中皮腫診療ガイドライン2016年版.  EBMの手法による肺癌診療ガイドライン 2016年版  221-273.  金原出版,  東京, 2016.12
5. Tadao Nakazawa, Tetsuo Kondo:  Endocrine lesions in the mammary glands.  Endocrine Pathology  858-867.  Cambridge University Press,  London, UK, 2016.7
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■ Academic conference presentation
1. ◎Yoshiaki Kinoshita, Tomoyuki Hida, Makoto Hamasaki, Shinji Matsumoto, Tohru Tsujimura, Kunimitsu
Kawahara, Kenzo Hiroshima, Yoshinao Oda, Kazuki Nabeshima: A Combination of MTAP and BAP1 Immunohistochemistry Is Useful for Differentiating Malignant and Benign Mesothelial Proliferatons in Tissue and Cytological Specimen.  2017 USCAP Annual Meeting,  San Antonio, USA,  2017/03
2. ◎Lauren E Rosen, Vijayalakshmi Ananthanarayanan, Alexander Gallan, Melissa Yuwono Tjota, Richard
Attanoos, Fouad S Alchami, Luka Brcic, Kelly Butnor, Kenzo Hiroshima, Astero Klampatsa, Leslie Litzky,
Alberto M Marchevsky, Filomena Medeiros, M Angeles Montero-Fernandez, David A Moore, Kazuki Nabeshima, Elizabeth N Pavlisko, Anupama Sharma, Michael Sheaff, Ann E Walts, Francoise Galateau,
Nolwenn Le Stang, Thomas Krausz, Aliya N Husain: Nuclear Grade, Necrosis and Solid Growth Pattern Predict Survival in Epithelioid Malignant Mesothelioma: An International, Multi-Institutional Study.  2017 USCAP Annual Meeting,  San Antonio, USA,  2017/03
3. ◎Andrew Nicholson, Patrizia Viola, Kathleen Torkko, Edwina Duhig, Kim Geisinger, Alain Borczuk, Kenzo Hiroshima, Ming Tsao, Arne Warth, Sylvie Lantuejoul, Prudence Russell, Erik Thunnissen, Alberto Marchevsky, Mari Mino-Kenudson, Mary Beth Beasley, Johan Botling, Sanja Dacic, Yasushi Yatabe, Masayuki Noguchi, William Travis, Keith Kerr, Fred R. Hirsch, Lucian Chirieac, Ignacio Wistuba, Andre Moreira, Jin-Haeng Chung, Teh Ying Chou, Lukas Bubendorf, Gang Chen, Giuseppe Pelosi, Claudia Poleri, Wilbur Franklin: REPRODUCIBILITY OF COMPREHENSIVE HISTOLOGIC ASSESSMENT AND REFINING HISTOLOGIC CRITERIA IN P STAGING OF MULTIPLE TUMOUR NODULES.  IASLC 17th World Conference on Lung Cancer,  Vienna, Austria,  2016/12
4. ◎Kenzo Hiroshima, Di Wu, Yasuo Sekine, Daisuke Ozaki, Toshikazu Yusa, Kouta Washimi, Reiji Haba, Yuji Tada, Hideaki Shimada, Masatoshi Tagawa: BAP1 immunostaining and FISH analysis of p16 help making distinction among subtypes of mesotheliomas.  IASLC 17th World Conference on Lung Cancer,  Vienna, Austria,  2016/12
5. ◎Masatoshi Tagawa, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima: Preclinical and clinical researches for malignant mesothelioma with gene medicine and bisphosphonates.  International Society for Cell and Gene Therapy of Cancer,  Seoul, Korea,  2016/11
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