MURAGAKI Yoshihiro    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Visiting Professor
Language	Japanese
Title	Development of Autofocus Surgical Microscope for Neurosurgery with Fluorescence Spectra Measurement
Conference Type	Nationwide Conferences
Presentation Type	Speech
Date	2008/10/31
Society abstract	日本コンピュータ外科学会誌 10(3),297-298 2008
Summary	Abstract: It is important to remove tumor accurately in neurosurgery, such as the resection of malignant glioma. However, gross total removal is difficult for glioma extending eloquent area to preserve important brain function. 5-Aminolevulinic Acid (5-ALA) accumulates on tumors and metabolizes to ProtoporphyrinlX (PpIX), which is a fluorescent substance. Intra-operative detection of 5-ALA-induced PpIX fluorescence provides useful information for tumor detection. In this study, we developed an automatically focusing surgical microscope system with a guide laser measurement. The system is connected with a fluorescence spectra measurement device, which can detect the fluorescence in tumor detection. We performed a set of experiments for evaluation of the autofocus device and measurement of the fluorescence spectra. Experimental Results showed that the accuracy of autofocus largely depends on the scattering of the guide laser and the condition of the brain surface. Our future works include the improvement of the accuracy of autofocus device and installation of tumor evaporation ablation laser to the microscope system.