Miyata Mariko    Department   School of Medicine, School of Medicine    Position   Professor and Division head
Language	English
Title	Transection of infraorbital nerve induces multiple innervations of lemniscal fibers onto the relay neuron in the somatosensory thalamus.
Conference	The 32nd Annual Meeting of the Japan Neuroscience Society
Conference Type	Nationwide Conferences
Presentation Type	Poster notice
Lecture Type	General
Publisher and common publisher	◎Takeuchi Y, Imoto K, Miyata M
Date	2009/09/17
Venue (city and name of the country)	Nagoya, Japan
Society abstract	Neuroscience Research 65(Suppl. 1),S145 2009
Summary	Lesion of peripheral sensory nerve induces reorganization of receptive field in the somatosensory thalamus (VPm). However, it is still unknown functional changes of the individual lemniscal synapse, which convey primary somatosensory inputs to VPm, underlie this phenomenon. Our electrophysiological study has previously demonstrated that the thalamic relay neuron becomes to receive a single lemniscal fiber by postnatal days 21 (P21) after developmental synapse elimination in the rodent VPm. Here, we show that the transection of infraorbital nerve at P21 altered the wiring of this synapse. After 1 week from the surgery, multiple steps of lemniscal EPSCs were observed, implying the additional recruitment of lemniscal fibers. Multiply innervated relay neurons occasionally contained silent synapses which were absent in normal young adult mice. These results indicate the lesion-induced rewiring of lemniscal fibers in the VPm.