ヒロシマ　ケンゾウ   廣島　健三    所属   その他 その他    職種   登録医
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Lung carcinogenesis from chronic obstructive pulmonary disease: characteristics of lung cancer from COPD and contribution of signal transducers and lung stem cells in the inflammatory microenvironment
掲載誌名	正式名：General thoracic and cardiovascular surgery 略　 称：Gen Thorac Cardiovasc Surg ISSNコード：1863-6713 (Electronic)1863-6705 (Linking)
巻・号・頁	62(7),pp.415-21
著者・共著者	Sekine, Y†. Hata, A. Koh, E. Hiroshima, K.
担当区分	最終著者
発行年月	2014/07
概要	Chronic obstructive pulmonary disease (COPD) and lung cancer are closely related. The annual incidence of lung cancer arising from COPD has been reported to be 0.8-1.7 %. Treatment of lung cancer from COPD is very difficult due to low cardiopulmonary function, rapid tumor growth, and resistance to molecularly targeted therapies. Chronic inflammation caused by toxic gases can induce COPD and lung cancer. Carcinogenesis in the inflammatory microenvironment occurs during cycles of tissue injury and repair. Cellular damage can induce induction of necrotic cell death and loss of tissue integrity. Quiescent normal stem cells or differentiated progenitor cells are introduced to repair injured tissues. However, inflammatory mediators may promote the growth of bronchioalveolar stem cells, and activation of NF-kappaB and signal transducer and activator of transcription 3 (STAT3) play crucial roles in the development of lung cancer from COPD. Many of the protumorgenic effects of NF-kappaB and STAT3 activation in immune cells are mediated through paracrine signaling. NF-kappaB and STAT3 also contribute to epithelial-mesenchymal transition. To improve lung cancer treatment outcomes, lung cancer from COPD must be overcome. In this article, we review the characteristics of lung cancer from COPD and the mechanisms of carcinogenesis in the inflammatory microenvironment. We also propose the necessity of identifying the mechanisms underlying progression of COPD to lung cancer, and comment on the clinical implications with respect to lung cancer prevention, screening, and therapy.
DOI	10.1007/s11748-014-0386-x
文献番号	24627306