KONDO Mitsuko    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Professor (Fixed Term)
Article types	Original article
Language	English
Peer review	Non peer reviewed
Title	Coexistence of diffuse panbronchiolitis and asthma: reciprocity of neutrophilic and eosinophilic inflammation.
Journal	Formal name：Respirology case reports Abbreviation：Respirol Case Rep ISSN code：2051-3380(Linking)
Domestic / Foregin	Foregin
Volume, Issue, Page	5(3),pp.e00232
Author and coauthor	TAKEYAMA Kiyoshi†, SHIMIZU Yuri, ISHII Masanobu, HARA Hiroko, KONDO Mitsuko, TAMAOKI Jun
Publication date	2017/05
Summary	Diffuse panbronchiolitis (DPB) and asthma are obstructive airway diseases, the former being characterized by Th1-type and the latter by Th2-type airway inflammation. Differential diagnosis is often a problem, but coexistence has rarely been reported. A 76-year-old man with asthma was admitted to our hospital because of one-month history of dyspnoea on exertion with bilateral diffuse granular shadows. He also had a history of chronic sinusitis. Auscultation of the lungs showed coarse crackles and wheezes. Laboratory data revealed an elevated total serum immunoglobulin E and a high titre of cold agglutinin. Bronchoscopic evaluations of the shadows revealed compatible pathological findings in both DPB and asthma. Low-dose macrolide caused a prompt reduction of symptoms, along with improvements in radiographic findings and pulmonary functions, whereas the eosinophilic airway inflammation transiently worsened. When DPB and asthma coexist, the balance of Th1/Th2 immune response may be reciprocally altered by therapeutic intervention.
DOI	10.1002/rcr2.232
PMID	28392920