ツチヤ　ケン   TSUCHIYA Ken   土谷　健    所属   医学部 医学科（東京女子医科大学病院）    職種   特任教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Proteinuria is a simple sign of systemic inflammation that leads to a poor prognosis in individuals affected with non-Hodgkin lymphoma.
掲載誌名	正式名：Clinical nephrology 略　 称：Clin Nephrol ISSNコード：0301-0430(Print)0301-0430(Linking)
巻・号・頁	82(1),pp.51-7
著者・共著者	Hara Masaki†, Ando Minoru, Maeda Yoshiharu, Tsuchiya Ken, Nitta Kosaku
発行年月	2014/07
概要	BACKGROUND:The clinical significance of proteinuria has not been fully understood among patients who are affected with non-Hodgkin lymphoma (NHL).METHODS:A 1-year prospective cohort study was conducted to ascertain the association between proteinuria and mortality in 46 hospitalized NHL patients. Proteinuria was defined as persistent dipstick testMETHODS:>METHODS:= 1+, and the urinary protein creatinine ratio (UPCR),as a quantitative index of protein excretion, was measured simultaneously. A multivariable linear regression model was constructed to determine factors associated with UPCR. Statistical associations between proteinuria and time to mortality were analyzed using the Kaplan-Meier method and multivariable proportional hazards regression analysis, adjusted for covariates including disease severity, renal function, and serum interleukin-6(IL-6) concentration.RESULTS:The prevalence of proteinuriaRESULTS:was 15.2% in the NHL patients. UPCR was significantly associated with the serum IL-6 level (standardized beta = 0.360, p = 0.0440). The cumulative mortality was significantly higher in proteinuric patients than in non-proteinuric patients, with a graded relationship between the severity of UPCR and mortality. The mortality risk increased with increasing UPCR grade: the hazard ratio (95% confidence interval) was 4.90 (1.29 - 32.3) for UPCR 30 - 300 mg/gand 17.8 (2.84 - 150) for UPCRRESULTS:>RESULTS:300 mg/g, respectively, when UPCRRESULTS:<RESULTS:30 mg/g was set as the reference.CONCLUSIONS:Proteinuria is a simple sign of coexisting systemic inflammation due to NHL and a harbinger of a poor prognosis.
DOI	10.5414/CN108132
文献番号	24887301