キタガワ　カズオ   KITAGAWA KAZUO   北川　一夫    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Common carotid intima-media thickness relates to cardiovascular events in adults aged <45 years.
掲載誌名	正式名：Hypertension (Dallas, Tex. : 1979) 略　 称：Hypertension ISSNコード：(1524-4563)0194-911X(Linking)
掲載区分	国外
巻・号・頁	65(4),pp.707-13
著者・共著者	Eikendal Anouk L M, Groenewegen Karlijn A, Anderson Todd J, Britton Annie R, Engström Gunnar, Evans Greg W, de Graaf Jacqueline, Grobbee Diederick E, Hedblad Bo, Holewijn Suzanne, Ikeda Ai, Kitagawa Kazuo, Kitamura Akihiko, Lonn Eva M, Lorenz Matthias W, Mathiesen Ellisiv B, Nijpels Giel, Dekker Jacqueline M, Okazaki Shuhei, O'Leary Daniel H, Polak Joseph F, Price Jacqueline F, Robertson Christine, Rembold Christopher M, Rosvall Maria, Rundek Tatjana, Salonen Jukka T, Sitzer Matthias, Stehouwer Coen D A, Hoefer Imo E, Peters Sanne A E, Bots Michiel L, den Ruijter Hester M,
発行年月	2015/04
概要	Although atherosclerosis starts in early life, evidence on risk factors and atherosclerosis in individuals aged <45 years is scarce. Therefore, we studied the relationship between risk factors, common carotid intima-media thickness (CIMT), and first-time cardiovascular events in adults aged <45 years. Our study population consisted of 3067 adults aged <45 years free from symptomatic cardiovascular disease at baseline, derived from 6 cohorts that are part of the USE-IMT initiative, an individual participant data meta-analysis of general-population-based cohort studies evaluating CIMT measurements. Information on risk factors, CIMT measurements, and follow-up of the combined end point (first-time myocardial infarction or stroke) was obtained. We assessed the relationship between risk factors and CIMT and the relationship between CIMT and first-time myocardial infarction or stroke using a multivariable linear mixed-effects model and a Cox proportional-hazards model, respectively. During a follow-up of 16.3 years, 55 first-time myocardial infarctions or strokes occurred. Median CIMT was 0.63 mm. Of the risk factors under study, age, sex, diastolic blood pressure, body mass index, total cholesterol, and high-density lipoprotein cholesterol related to CIMT. Furthermore, CIMT related to first-time myocardial infarction or stroke with a hazard ratio of 1.40 per SD increase in CIMT, independent of risk factors (95% confidence interval, 1.11-1.76). CIMT may be a valuable marker for cardiovascular risk in adults aged <45 years who are not yet eligible for standard cardiovascular risk screening. This is especially relevant in those with an increased, unfavorable risk factor burden.
DOI	10.1161/HYPERTENSIONAHA.114.04658
PMID	25624341