ナカミゾ　ムネナガ   中溝　宗永    所属   医学部 医学科（東京女子医科大学病院）    職種   特任教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Partial laryngectomy in the treatment of radiation-failure of early glottic carcinoma.
掲載誌名	正式名：Head & neck 略　 称：Head Neck ISSNコード：10433074/10433074
掲載区分	国外
巻・号・頁	19(2),pp.116-120
著者・共著者	NIBU Kenichi, KAMATA Shin-etsu, KAWABATA Kazuyoshi, NAKAMIZO Munenaga, NIGAURI Tomohiko, HOKI Katsufumi
発行年月	1997/03
概要	BACKGROUND:This study was undertaken to analyze the functional results, complications, local control rates, and survival in patients undergoing conservation surgery for squamous cell carcinoma (SCC) of the larynx as a salvage procedure for recurrent tumors after previous radiotherapy.METHODS:Twenty-one patients underwent frontolateral laryngectomy for radiation failure, T1 and T2 glottic SCC, at the Cancer Institute Hospital, Tokyo, from 1976 to 1991. All patients were men between the ages of 42 and 83 years. The disease-free interval ranged from 1 to 87 months (median, 26 months). The stage at initial treatment was T1 in 17 patients and T2 in four patients. Local recurrence developed in three patients.RESULTS:The rate of local control was influenced by a surgical margin of less than 1 mm (p < 0.05). Overall voice preservation was achieved in 86% of the patients. The 5-year and 10-year survival rates following frontolateral laryngectomy were 86% and 70%, respectively. Maximum phonation time after surgery ranged from 4 to 18 seconds (median, 8.1 seconds).CONCLUSIONS:These results indicate that in carefully selected cases, frontolateral laryngectomy may be used for treating radiation failure stage I or II vocal cord carcinomas with good success. Careful follow-up may be necessary in patients with a close surgical margin.
DOI	10.1002/(sici)1097-0347(199703)19:2<116::aid-hed5>3.0.co;2-7
PMID	9059868