ナカミゾ　ムネナガ   中溝　宗永    所属   医学部 医学科（東京女子医科大学病院）    職種   特任教授
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type, with Primary Manifestation as an Upper Eyelid Swelling.
掲載誌名	正式名：Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 略　 称：J Nippon Med Sch ISSNコード：13473409/13454676
掲載区分	国外
巻・号・頁	83(4),pp.177-179
著者・共著者	Kanzaki Akiko, Funasaka Yoko, Nakamizo Munenaga, Shima Ayaka, Ryotokuji Takeshi, Dan Kazuo, Terasaki Mika, Sugisaki Yuichi, Fukuda Yu, Kawana Seiji, Saeki Hidehisa
発行年月	2016
概要	Extranodal natural killer/T-cell lymphoma (ENK/TCL) is most often in the nose or the nasopharynx but can present elsewhere. We report a rare case of ENK/TCL that presented as swelling of an upper eyelid without ocular involvement. A 76-year-old man visited our hospital with a swollen lesion of the left upper eyelid which had appeared 2 months earlier. A biopsy of the upper eyelid revealed slight perivascular and periadnexal infiltration of mononuclear cells with dermal edema. Treatment with oral prednisolone at a dosage of 20 mg/day decreased the eyelid swelling. However, 5 months later, exacerbation of the swelling and nasal congestion were observed. A second biopsy of the upper eyelid revealed a diffuse dermal infiltrate composed of mononuclear cells with an angiocentic growth pattern. Immunohistochemical studies and in situ hybridization showed natural killer-lineage antigens (CD56, granzyme B, and T-cell intracellular antigen 1) with expression of Epstein-Barr virus. These findings lead to the diagnosis of ENK/TCL. We treated the patient with radiation therapy (50 Gy) and 3 courses of a regimen including dexamethasone, carboplatin, etoposide, and ifosphamide. This case suggests that ENK/TCL can present with swelling of an upper eyelid as the primary sign of the skin lesion. Swelling of an upper eyelid should be considered in the differential diagnosis of ENK/TCL.
DOI	10.1272/jnms.83.177
PMID	27680487