Nagashima, Yoji    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Professor and Division head
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Atypical protein kinase C λ/ι expression is associated with malignancy of oral squamous cell carcinoma.
Journal	Formal name：Anticancer research Abbreviation：Anticancer Res ISSN code：02507005/17917530
Domestic / Foregin	Foregin
Volume, Issue, Page	38(11),pp.6291-6297
Author and coauthor	Baba J†, Kioi M*, Akimoto K, Nagashma Y, Taguri M, Inayama Y, Aoki I, Ohno S, Mitsudo K, Tohnai I
Publication date	2018/11
Summary	BACKGROUND/AIM: Atypical protein kinase C λ/ι (aPKCλ/ι) is a cell polarity-regulator localized in the tight junction and apical membrane in epithelial cells. Previous studies suggested that aPKCλ/ι overexpression and abnormal localization were involved in tumor progression in several cancers. We investigated the relationship between aPKCλ/ι and oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS: The correlation between the aPKCλ/ι expression and the clinicopathological parameters in 76 OSCC cases was examined using immunohistochemical analyses. RESULTS: aPKCλ/ι overexpression was observed in 36.8% of cases. aPKCλ/ι expression was more intense in poorly differentiated OSCC and younger patients (<60 years of age). Although expression of aPKCλ/ι was not significantly associated with clinical parameters, the correlation was found between aPKCλ/ι localization and progression-free survival. CONCLUSION: This is the first study to assess the association of aPKCλ/ι expression in OSCC with clinical results. Expression and localization of aPKCλ/ι may be involved in the degree of malignancy in OSCC.
DOI	10.21873/anticanres.12985
PMID	30396949