Nagashima, Yoji    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Professor and Division head
Article types	Review article
Language	Japanese
Peer review	Peer reviewed
Presence of invitation	Invited paper
Title	Pathological diagnosis of renal tumors: up to date
Journal	Formal name：Ｃｌｉｎｉｃａｌ　Ｐａｔｈｏｌｏｇｙ
Volume, Issue, Page	pp.568-577
Author and coauthor	Nagashima Y, Aoki I, Kondo K, Nakaigawa N, Kishida T, Miyagi Y, Yao M.
Authorship	Lead author,Corresponding author
Publication date	2014/06
Summary	Renal cell carcinoma (RCC) is composed of heterogenous histological types, with different clinical features and molecular biological characteristics. The "General Rule for Clinical and Pathological Studies on RCC" was revised in 2011, according to the World Health Organization system (WHO) (2004). Although most RCC is clear cell RCC (approximately 70-80% of RCC), papillary and chromophobe RCCs are occasionally encountered (approximately 10 and 5%, respectively). Collecting duct carcinoma is a rare and highly aggressive adenocarcinoma derived from the collecting duct. Additionally, several histological types have been introduced, and "granular RCC" has been omitted as a diagnostic term. For precise diagnosis, careful gross and histological evaluations are required along with immunohistochemical and molecular biological analyses. Additionally, novel histological types have recently been emerging, i.e., 6p21 translocation-associated RCC, dialysis-associated RCC, and tubulocystic carcinoma. Furthermore, mimics of RCC are always considered as differential diagnostic candidates, i.e., metanephric adenoma, epithelioid angiomyolipoma, juxtaglomerular cell tumor, and carcinoid tumor.
PMID	25151776