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Kikuchi Ken
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | The clinical utility of a near patient care rapid microarray-based diagnostic test for influenza and respiratory syncytial virus infections in the pediatric setting. |
| Journal | Formal name：Diagnostic microbiology and infectious disease Abbreviation：Diagn Microbiol Infect Dis ISSN code：(1879-0070)0732-8893(Linking) |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 78(4),pp.363-7 |
| Author and coauthor | Nakao Akihiro, Hisata Ken, Matsunaga Nobuaki, Fujimori Makoto, Yoshikawa Naomi, Komatsu Mitsutaka, Kikuchi Ken, Takahashi Hiroshi, Shimizu Toshiaki |
| Publication date | 2014/04 |
| Summary | We evaluated the potential clinical utility of an automated near patient molecular assay Verigene Respiratory Virus Plus (RV+) and rapid immunochromatographic antigen tests (RIAT) in the pediatric setting for diagnosis of influenza and respiratory syncytial virus infections when testing was performed by the pediatrician seeing the patient. Overall, with respect to influenza virus, sensitivity and specificity for RIAT were 70.8% and 100%, respectively, compared to 100% and 96.2%, respectively, for RV+. For respiratory syncytial virus, sensitivity and specificity for RIAT were 78.9% and 100%, respectively, compared to 100% and 100%, respectively, for RV+. When RIAT and RV+ sensitivity for influenza virus was compared based on the time the patient presented after onset of fever, the sensitivity of RIAT at 6 hours was 37.5% compared to 100% for RV+. At 12 hours, RIAT improved to 60.9%. This study confirms the clinical utility of RV+ in the pediatric setting. |
| DOI | 10.1016/j.diagmicrobio.2013.11.005 |
| PMID | 24582577 |