セキネ　ヤスオ   SEKINE YASUO   関根　康雄    所属   医学部 医学科（附属八千代医療センター）    職種   客員教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Lung carcinogenesis from chronic obstructive pulmonary disease: characteristics of lung cancer from COPD and contribution of signal transducers and lung stem cells in the inflammatory microenvironment.
掲載誌名	正式名：General thoracic and cardiovascular surgery 略　 称：Gen Thorac Cardiovasc Surg ISSNコード：(1863-6713)1863-6705(Linking)
巻・号・頁	62(7),pp.415-21
著者・共著者	Sekine Yasuo, Hata Atsushi, Koh Eitetsu, Hiroshima Kenzo
発行年月	2014/07
概要	Chronic obstructive pulmonary disease (COPD) and lung cancer are closely related. The annual incidence of lung cancer arising from COPD has been reported to be 0.8-1.7 %. Treatment of lung cancer from COPD is very difficult due to low cardiopulmonary function, rapid tumor growth, and resistance to molecularly targeted therapies. Chronic inflammation caused by toxic gases can induce COPD and lung cancer. Carcinogenesis in the inflammatory microenvironment occurs during cycles of tissue injury and repair. Cellular damage can induce induction of necrotic cell death and loss of tissue integrity. Quiescent normal stem cells or differentiated progenitor cells are introduced to repair injured tissues. However, inflammatory mediators may promote the growth of bronchioalveolar stem cells, and activation of NF-κB and signal transducer and activator of transcription 3 (STAT3) play crucial roles in the development of lung cancer from COPD. Many of the protumorgenic effects of NF-κB and STAT3 activation in immune cells are mediated through paracrine signaling. NF-κB and STAT3 also contribute to epithelial-mesenchymal transition. To improve lung cancer treatment outcomes, lung cancer from COPD must be overcome. In this article, we review the characteristics of lung cancer from COPD and the mechanisms of carcinogenesis in the inflammatory microenvironment. We also propose the necessity of identifying the mechanisms underlying progression of COPD to lung cancer, and comment on the clinical implications with respect to lung cancer prevention, screening, and therapy.
DOI	10.1007/s11748-014-0386-x
PMID	24627306