タバタ　ツトム   TABATA Tsutomu   田畑　務    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
招待の有無	招待あり
表題	A retrospective study for investigating the outcomes of endometrial cancer treated with radiotherapy.
掲載誌名	正式名：International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 略　 称：Int J Gynaecol Obstet ISSNコード：18793479/00207292
掲載区分	国外
巻・号・頁	pp.13725
著者・共著者	Sakai Kensuke, Yamagami Wataru, Machida Hiroko, Ebina Yasuhiko, Kobayashi Yoichi, Tabata Tsutomu, Kaneuchi Masanori, Nagase Satoru, Enomoto Takayuki, Aoki Daisuke, Mikami Mikio
発行年月	2021/04
概要	OBJECTIVE:To clarify the role of radiotherapy for endometrial cancer.METHODS:Data were analyzed for 39 247 patients with endometrial cancer registered with the Gynecologic Cancer Registry of the Japan Society of Obstetrics and Gynecology from 2004 to 2011.RESULTS:The rates of 5-year overall survival (5y-OS) in the radiotherapy and surgery groups were 53.6% and 94.5% in stage I or II, and 15.5% and 67.5% in stage III or IV, respectively. The prognosis in the radiotherapy group was significantly poorer than that in the surgery group. In multivariate analysis, age, advanced stage, histological type, risk of recurrence, and initial radiotherapy were independent prognostic factors. The rates of 5y-OS with no adjuvant therapy, adjuvant chemotherapy, and adjuvant radiotherapy were 95.3%, 92.9%, and 87.1% for stage I or II, respectively, with significant differences among all groups (P < 0.001), and 60.0%, 70.4%, and 55.5% for stage III or IV, respectively, with significant differences of adjuvant chemotherapy with no adjuvant therapy (P < 0.001) and with adjuvant radiotherapy (P < 0.001). In multivariate analysis, age, advanced stage, histological type, lymphadenectomy, and adjuvant radiotherapy were independent prognostic factors.CONCLUSION:Patients treated with radiotherapy had a significantly poorer prognosis and the appropriate indication of radiotherapy for endometrial cancer requires further study.
DOI	10.1002/ijgo.13725
PMID	33914336