|
シガ ツヨシ
Tsuyoshi Shiga
志賀 剛 所属 医学部 医学科（東京女子医科大学病院） 職種 客員教授 |
|
| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Effects of telmisartan and valsartan on insulin sensitivity in obese diabetic mice. |
| 掲載誌名 | 正式名：European journal of pharmacology 略 称：Eur J Pharmacol ISSNコード：00142999/18790712 |
| 掲載区分 | 国外 |
| 出版社 | Elsevier |
| 巻・号・頁 | 698(1-3),pp.505-510 |
| 著者・共著者 | USHIJIMA Kentarou†, TAKUMA Masashi, ANDO Hitoshi, ISHIKAWA-KOBAYASHI Eiko, NOZAWA Masahiko, MAEKAWA Tomohiro, SHIGA Tsuyoshi, FUJIMURA Akio |
| 発行年月 | 2013/01 |
| 概要 | Telmisartan and valsartan have angiotensin II receptor blocking activity. Because telmisartan has also an agonistic action for peroxisome proliferators-activator receptor (PPAR)-γ, it is speculated that an effect of telmisartan on insulin sensitivity is different from that of valsartan, which lacks of PPAR-γ agonistic activity. To address the issue, effects of telmisartan and valsartan on insulin sensitivity, adipocytokines and PPAR-γ target genes were evaluated in obese diabetic mice. KK-A(y) mice were treated with telmisartan (5mg/kg) and valsartan (15 mg/kg), once daily for 3 weeks. Insulin tolerance test was performed on day 14, and plasma adiponectin concentration and mRNA expression levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in adipose tissues were measured on day 21. Time-course of plasma glucose level after the injection of insulin in mice with telmisartan was not significantly different from that of animals with valsartan. In addition, PPAR-γ antagonist did not diminished the improvement of insulin sensitivity by telmisartan. Telmisartan and valsartan elevated plasma adiponectin concentration and suppressed the mRNA expressions of TNF-α and IL-6 in adipose tissues. These variables of the telmisartan- and valsartan-treated groups did not significantly differ. Influence of telmisartan on the PPAR-γ target genes (ap2 and fatty acid synthase) mRNA expressions was not detected in adipose tissues under the present condition. These data suggest that the effect of telmisartan on insulin sensitivity is similar to that of valsartan, and a role of PPAR-γ-mediated stimuli is small in the telmisartan-induced improvement of insulin sensitivity. |
| DOI | 10.1016/j.ejphar.2012.11.022 |
| PMID | 23195328 |