シミズ　ユウコ   SHIMIZU Yuko   清水　優子    所属   医学部 医学科（東京女子医科大学病院）    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Topical naphazoline in the treatment of myasthenic blepharoptosis.
掲載誌名	正式名：Muscle & nerve 略　 称：Muscle Nerve ISSNコード：10974598/0148639X
掲載区分	国外
巻・号・頁	44(1),pp.41-4
著者・共著者	Nagane Yuriko, Utsugisawa Kimiaki, Suzuki Shigeaki, Masuda Masayuki, Shimizu Yuko, Utsumi Hiroya, Uchiyama Shinichiro, Suzuki Norihiro
発行年月	2011/07
概要	INTRODUCTION:When treating ocular myasthenia gravis (MG), the risk/benefit profile of corticosteroids is unclear, and acetylcholinesterase inhibitors are not very effective. We examined the efficacy of topical naphazoline in the treatment of myasthenic blepharoptosis.METHODS:Sixty MG patients with blepharoptosis (32 with ocular symptoms only and 28 with mild generalized symptoms) were enrolled in a multicenter open trial of topical naphazoline. The effects were reported by patients via a questionnaire and were also confirmed for each patient at the clinic.RESULTS:Among 70 eyes of 60 patients, 20 eyes (28.6%) of 17 patients (28.3%) exhibited a marked response (full eye opening), and 24 eyes (34.3%) of 20 patients (33.3%) showed a good response (adequate but incomplete eye opening). Topical naphazoline was evaluated as useful in the treatment of myasthenic blepharoptosis by >70% of the patients.CONCLUSIONS:Topical naphazoline was found to be an effective supplementary symptomatic treatment for myasthenic blepharoptosis.
DOI	10.1002/mus.22002
PMID	21491460