シミズ　ユウコ   SHIMIZU Yuko   清水　優子    所属   医学部 医学科（東京女子医科大学病院）    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	The MG-QOL15 Japanese version: validation and associations with clinical factors.
掲載誌名	正式名：Muscle & nerve 略　 称：Muscle Nerve ISSNコード：10974598/0148639X
掲載区分	国外
巻・号・頁	46(2),pp.166-17３
著者・共著者	Masuda Masayuki, Utsugisawa Kimiaki, Suzuki Shigeaki, Nagane Yuriko, Kabasawa Chiaki, Suzuki Yasushi, Shimizu Yuko, Utsumi Hiroya, Fujihara Kazuo, Uchiyama Shinichiro, Suzuki Norihiro
発行年月	2012/08
概要	INTRODUCTION:Our study aim was to produce a Japanese translation of the 15-item Myasthenia Gravis Quality-of-Life Scale (MG-QOL15), assess its reliability and validity, and examine clinical factors affecting self-perceived QOL in MG.METHODS:We evaluated 327 consecutive patients with MG seen at six neurological centers. All patients completed the Japanese version of the MG-QOL15 (MG-QOL15-J), the Beck Depression Inventory-second edition (BDI-II), and a generic health-related QOL questionnaire, the SF-36. Disease severity was determined according to the Myasthenia Gravis Foundation of America (MGFA) quantitative MG score and the MG composite.RESULTS:The MG-QOL15-J exhibited adequate internal reliability, test-retest repeatability, and concurrent validity with SF-36, disease severity, and known-patient groups categorized by MGFA post-intervention status. Multivariate analysis revealed severity, dose of oral corticosteroids, and BDI-II as independent factors negatively affecting QOL.CONCLUSION:The MG-QOL15-J is anticipated to be a valuable clinical measure of QOL in Japanese patients with MG.
DOI	10.1002/mus.23398
PMID	22806364