ナンケ　ユキ   Nanke Yuki   南家　由紀    所属   看護学部 看護学科    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Human receptor activator of NF-κB ligand (RANKL) induces osteoclastogenesis of primates in vitro.
掲載誌名	正式名：In vitro cellular & developmental biology. Animal 略　 称：In Vitro Cell Dev Biol Anim ISSNコード：(1543-706X)1071-2690(Linking)
掲載区分	国外
巻・号・頁	48(9),pp.593-8
著者・共著者	Kotake Shigeru, Yago Toru, Kawamoto Manabu, Nanke Yuki
発行年月	2012/10
概要	Mouse receptor activator of NF-κB ligand (RANKL), which induces osteoclastogenesis from monocytes or macrophages, was independently cloned by three groups in 1997. Mouse osteoclasts have been induced from peripheral monocytes stimulated by RANKL and macrophage colony-stimulating factor (M-CSF) both in vitro and in vivo; however, the mechanism of primate osteoclastogenesis has not been studied. In addition, the effects of human RANKL on primate osteoclastogenesis remain to be elucidated. Here, we investigated the effect of human RANKL on the osteoclastogenesis of monocytes from five subspecies of primates. Human RANKL induced osteoclastogenesis of all the primates. In addition, human RANKL induced pit formation by osteoclasts from monocytes of the crab-eating macaque. We also demonstrated that the primate osteoclastogenesis was inhibited by a novel peptide, which inhibited human osteoclastogenesis in our previous study. Thus, these findings clearly demonstrated that human RANKL induces primate osteoclastogenesis in the presence of human M-CSF.
DOI	10.1007/s11626-012-9549-1
PMID	23054440