|
ナガノ ヒロアキ
NAGANO HIROAKI
長野 浩明 所属 医学部 医学科（附属足立医療センター） 職種 准教授 |
|
| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Current status of tertiary debulking surgery
and prognosis after secondary debulking surgery for recurrent Müllerian epithelial cancer in Japan: a retrospective analysis of 164 patients (KCOG-G1402) |
| 掲載誌名 | 正式名：World Journal of Surgical Oncology ISSNコード：1477-7819 |
| 掲載区分 | 国外 |
| 出版社 | BioMed Central |
| 巻・号・頁 | 15(132),pp.1-7 |
| 著者・共著者 | Tomoko Hirakawa†*, Takeo Minaguchi, Yoshio Itani, Yuka Kasamatsu, Saki Murase, Shoko Sakurada, Hiroaki Nagano, Kazuhiro Takehara, Tomohiko Tsuruta, Atsushi Arakawa, Kouichiro Kawano, Hiroshi Tsubamoto, Takashi Ushiwaka, Taisuke Mori, Kana Iwai, Motoaki Saito, Hiroyuki Morisawa, Fumitaka Saito, Kenta Yoshida, Masanori Kaneuchi, Hiroki Sato, Kimihiko Ito, Kaei Nasu |
| 発行年月 | 2017/07 |
| 概要 | Background: This study aimed to evaluate the current status of secondary debulking surgery (SDS) and tertiary debulking surgery (TDS; performed for recurrence after SDS) and to assess the overall survival after recurrence of Müllerian epithelial cancer in Japan. We also evaluated the data of patients who underwent a fourth debulking surgery (i.e., quaternary debulking surgery (QDS)).
Methods: We conducted a retrospective study of 164 patients with recurrent Müllerian epithelial cancers (i.e., ovarian, tubal, and peritoneal cancers). The SDS was performed between January 2000 and September 2014 in 20 Japanese hospitals. Clinicopathological data were collected and analyzed. Results: Of the 164 patients, 66 patients did not have a recurrence or died after SDS. Ninety-eight patients had a recurrence after SDS. Forty-three of the 98 patients underwent TDS; 55 of the 98 patients did not undergo TDS and were classified into the non-TDS group. The overall survival (OS) after SDS was significantly better in the TDS group than in the non-TDS group. The median OS after SDS was 123 and 42 months in the TDS group and non-TDS group, respectively. Of the 43 patients who received TDS, 11 patients were further treated with QDS. The median OS after SDS was 123 months for patients who underwent QDS. Conclusions: This multicenter study on the prognosis of post-SDS is apparently the first report on QDS in Japan. Patients undergoing TDS have a good prognosis, compared to patients in the non-TDS group. Novel drugs are being evaluated; however, debulking surgery remains a necessary treatment for recurrence. Keywords: Müllerian epithelial cancer, Recurrence, Secondary debulking surgery, Tertiary debulking surgery, Quaternary debulking surgery |
| DOI | 10.1186/s12957-017-1200-x |