ヤマザキ　ケンジ   KENJI YAMAZAKI   山崎　健二    所属   医学部 医学科（東京女子医科大学病院）    職種   客員教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Circadian variation of motor current observed in fixed rotation speed continuous-flow left ventricular assist device support.
掲載誌名	正式名：Journal of Artificial Organs 略　 称：J. artif. organs ISSNコード：14347229/16190904
掲載区分	国内
出版社	Springer Japan KK
巻・号・頁	17(2),pp.157-161
著者・共著者	SUZUKI KENJI†, NISHINAKA Tomohiro, MIYAMOTO Takuma, ICHIHARA Yuki, YAMAZAKI Kenji
発行年月	2014/07
概要	The algorithm for the physiological control provided by left ventricular assist devices (LVADs) has been controversial. In particular, little is known about the physiological control algorithm (such as for achieving physiological circadian rhythms) in continuous-flow LVADs. To investigate the existence of circadian variation, we retrospectively evaluated the LVAD flow-correlated motor current of patients supported by continuous-flow LVADs. The motor current and the pump speed were collected from the external controller every 10 min after device implantation, and the data were divided for every 30-day period, which began on midnight on the first post-operative day. The subjects were 18 patients (mean age 37.7, mean body surface area 1.71 m(2) at the time of operation) with dilated cardiomyopathy or dilated phase of hypertrophic cardiomyopathy. As of August 1, 2013, the patients' median support duration was 889 days. The mean calculated dominant period of motor current variation was 24.0 h and the mean amplitude was 11.7 mA for the entire duration. The amplitude of the motor current circadian variation tended to be increased until around the fifth month. The motor current had a tendency to be relatively low during the night time and high during the day time. A significant difference was found between the night-time and day-time mean motor current for the entire duration (p < 0.05). In conclusion, the circadian variation of the motor current could be observed over long term in patients with fixed rotation speed continuous-flow LVAD support.
DOI	10.1007/s10047-014-0762-4
PMID	24715349