ナガオ　ミチノブ   長尾　充展    所属   医学部 医学科（東京女子医科大学病院）    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Heterogeneity of cerebral blood flow in frontotemporal lobar degeneration and Alzheimer's disease.
掲載誌名	正式名：European journal of nuclear medicine and molecular imaging 略　 称：Eur J Nucl Med Mol Imaging ISSNコード：(1619-7070)1619-7070(Linking)
掲載区分	国外
巻・号・頁	31(2),pp.162-168
著者・共著者	Nagao Michinobu, Sugawara Yoshifumi, Ikeda Manabu, Fukuhara Ryuji, Hokoishi Kazuhiko, Murase Kenya, Mochizuki Teruhito, Miki Hitoshi, Kikuchi Takanori
担当区分	筆頭著者,責任著者
発行年月	2004/02
概要	This study was designed to quantify the heterogeneity on cerebral blood flow single-photon emission tomography (SPET) images in frontotemporal lobar degeneration (FTLD) and Alzheimer's disease (AD) using a three-dimensional fractal analysis. Twenty-one FTLD patients, 21 AD patients and 11 healthy controls underwent technetium-99m hexamethylpropylene amine oxime SPET scanning. Patients with FTLD and AD matched for sex, age and the severity of dementia as estimated with the Clinical Dementia Rating and were determined to be in the early stage of illness. We delineated the SPET images using a 35% cut-off and a 50% cut-off of the maximal voxel radioactivity and measured the number of voxels included in the contours of two different cut-offs. The fractal dimension (FD) was calculated by relating the logarithms of the cut-offs and the numbers of voxels, and it was defined as the heterogeneity of the cerebral perfusion. We divided the SPET images into two sets, anterior and posterior, with equal numbers of coronal SPET slices. We calculated total FD, anterior FD and posterior FD for total, anterior and posterior SPET images. Anterior FDs for FTLD and AD were 1.55 +/- 0.34 and 1.24 +/- 0.19 (P = 0.0002). The ratios of anterior to posterior FD for FTLD and AD were 1.81 +/- 0.41 and 1.32 +/- 0.14 (P < 0.0001). Use of the anterior FD and the ratio of anterior to posterior FD separated FTLD patients from AD patients and controls with a sensitivity of 85.7% and a specificity of 93.8%. Anterior FD and the ratio of anterior to posterior FD may be useful in distinguishing FTLD from AD.
DOI	10.1007/s00259-003-1343-6
PMID	15129697