ヤスカワ　クミ   安川　久美    所属   医学部 医学科（附属八千代医療センター）    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Infantile traumatic brain injury with a biphasic clinical course and late reduced diffusion.
掲載誌名	正式名：Journal of the neurological sciences 略　 称：J Neurol Sci ISSNコード：18785883/0022510X
掲載区分	国内
巻・号・頁	390,pp.63-66
著者・共著者	Takase Nanako, Igarashi Noboru, Taneichi Hiromichi, Yasukawa Kumi, Honda Takafumi, Hamada Hiromichi, Takanashi Jun-Ichi
発行年月	2018/07
概要	Reduced diffusion in the subcortical white matter has been reported in some infants with traumatic brain injury (TBI), including abusive head trauma. However, the pathomechanisms of the lesions and clinical features are uncertain. We herein report two infants with TBI who presented with biphasic clinical courses and late reduced diffusion in the subcortical white matter, and reviewed seven clinically and radiologically similar patients with TBI. Their clinical features (secondary neurological symptoms on days 3 to 6) and radiological findings (normal diffusion on days 1 to 2, followed by reduced diffusion on days 3 to 6) are very similar to those observed in patients with acute encephalopathy with biphasic seizures and late reduced diffusion (AESD). MR spectroscopy in one patient revealed a transient increase of glutamine, which is also observed in AESD, suggesting excitotoxicity as a possible pathomechanism.
DOI	10.1016/j.jns.2018.04.010
PMID	29801909