トキタ　ダイスケ   TOKITA Daisuke   時田　大輔    所属   医学部 医学科（東京女子医科大学病院）    職種   非常勤講師
論文種別	総説
言語種別	英語
査読の有無	査読あり
表題	Dendritic cell immunobiology in relation to liver transplant outcome.
掲載誌名	正式名：Frontiers in bioscience (Elite edition) 略　 称：Front Biosci (Elite Ed) ISSNコード：19450508/19450494
掲載区分	国外
巻・号・頁	1,pp.99-114
著者・共著者	Sumpter Tina L, Lunz John G, Castellaneta Antonino, Matta Benjamin, Tokita Daisuke, Turnquist Heth R, Mazariegos George V, Demetris A Jake, Thomson Angus W
発行年月	2009/06
概要	The unique immunologic environment of the liver, together with its anatomic location downstream of the gut, influences the maturation and function of its interstitial dendritic cell (DC) populations. These well-equipped, antigen-presenting cells play critical roles in regulation of innate and adaptive immunity. New information is emerging about the molecular regulation of liver DC maturation and function, and their tolerogenic potential, while new insight is being gained regarding interactions between liver DC and other immune effector cell populations (NK, NKT cells) in addition to T cells. During transplantation, factors that affect liver DC biology include ischemia-reperfusion injury, liver regeneration, viral infection and the actions of anti-inflammatory and immunosuppressive drugs. Herein, we review the molecular and cell biology of hepatic DC populations in relation to the regulation of alloimmune responses and liver transplant outcome.
PMID	19482629