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ナルミヤ コウスケ
NARUMIYA Kosuke
成宮 孝祐 所属 医学部 医学科（東京女子医科大学病院） 職種 非常勤講師 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | Prognostic impact of carcinoembryonic antigen in 1822 surgically treated esophageal squamous cell carcinoma: multi-institutional study of the Japan Esophageal Society. |
| 掲載誌名 | 正式名：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 略 称：Dis Esophagus ISSNコード：14422050/11208694 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 35(12),pp.doac029 |
| 著者・共著者 | SUZUKI Takashi, YAJIMA Satoshi, OKAMURA Akihiko, YOSHIDA Naoya, TANIYAMA Yusuke, MURAKAMI Kentaro, OHKURA Yu, NAKAJIMA Yasuaki, YAGI Koichi, FUKUDA Takashi, OGAWA Ryo, HOSHINO ISAMU, KUNISAKI Chikara, NARUMIYA Kosuke, TSUBOSA Yasuhiro, YAMADA Kazuhiko, SHIMADA Hideaki, |
| 発行年月 | 2022/12 |
| 概要 | BACKGROUND:Previous studies have evaluated the clinicopathological significance of carcinoembryonic antigen (CEA) of esophageal cancer in relatively small numbers of patients. Therefore, this study aimed to clarify the prognostic significance of CEA in 1822 patients with esophageal squamous cell carcinoma (SCC).METHODS:Based on the Japanese Esophageal Society nationwide multi-institutional retrospective study, a total of 1,748 surgically treated ESCC from 15 hospitals were enrolled to evaluate prognostic impact of preoperative CEA values. Among them, 605 patients were categorized to up-front surgery group, and 1,217 patients were categorized to neoadjuvant therapy group. The CEA threshold for positivity was 3.7 ng/ml. The clinicopathological and prognostic impact of CEA was evaluated by univariate and multivariate analysis in each treatment modality groups.RESULTS:In total, the CEA positive rate was 25.8% (470/1822). CEA-positive status was significantly associated with distant metastasis (P = 0.004) but not associated with other factors. CEA-positive status was associated with poor overall survival (P < 0.001) in univariate analysis as well as multivariate analysis (P = 0.003).CONCLUSIONS:CEA was an independent prognostic determinant of overall survival in esophageal SCC. Based on the subgroup analysis, regardless of the treatment modality, patients with high pretreatment CEA showed poor overall survival. |
| DOI | 10.1093/dote/doac029 |
| PMID | 35661884 |