石井　泰雄    Department   Center for Medical and Nursing Education, Center for Medical and Nursing Education    Position   Assistant Professor
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Sonic hedgehog expression in developing chicken digestive organs is regulated by epithelial-mesenchymal interactions.
Journal	Formal name：Development, growth & differentiation Abbreviation：Dev Growth Differ ISSN code：(0012-1592)0012-1592(Linking)
Domestic / Foregin	Foregin
Volume, Issue, Page	40(1),pp.67-74
Author and coauthor	Narita T, Ishii Y, Nohno T, Noji S, Yasugi S
Authorship	2nd author
Publication date	1998/02
Summary	Sonic hedgehog (Shh) gene encodes a secreted protein that acts as an important mediator of cell-cell interactions. A detailed analysis of Shh expression in the digestive organs of the chicken embryo was carried out. Shh expression in the endoderm begins at stage 7, when the formation of the foregut commences, and is found as narrow bands in the midgut. Shh expression around the anterior intestinal portal at stage 15 is restricted to the columnar endoderm lined by the thick splanchnic mesoderm, suggesting that the existence of thick splanchnic mesoderm might be necessary for Shh expression in the columnar endoderm. After the gut is closed, Shh expression is found universally in digestive epithelia, including the cecal epithelium. However, its expression ceases in the epithelium of the proventricular glands, the ductus choledochus and ductus pancreaticus that protrude from the main digestive duct. When the gizzard epithelium differentiated into glands under the influence of the proventricular mesenchyme, the glandular epithelium lost the ability to express Shh. These findings suggest that Shh expression in the epithelium may be regulated by surrounding mesenchyme throughout organogenesis of the digestive organs and is closely involved in epithelial-mesenchymal interactions in developing digestive organs.
PMID	9563912