石井　泰雄    Department   Center for Medical and Nursing Education, Center for Medical and Nursing Education    Position   Assistant Professor
Article types	Review article
Language	English
Peer review	Peer reviewed
Title	Endothelial cell lineages of the heart.
Journal	Formal name：Cell and tissue research Abbreviation：Cell Tissue Res ISSN code：(1432-0878)0302-766X(Linking)
Domestic / Foregin	Foregin
Volume, Issue, Page	335(1),pp.67-73
Author and coauthor	Ishii Yasuo, Langberg Jonathan, Rosborough Kelley, Mikawa Takashi
Publication date	2009/01
Summary	During early gastrulation, vertebrate embryos begin to produce endothelial cells (ECs) from the mesoderm. ECs first form primitive vascular plexus de novo and later differentiate into arterial, venous, capillary, and lymphatic ECs. In the heart, the five distinct EC types (endocardial, coronary arterial, venous, capillary, and lymphatic) have distinct phenotypes. For example, coronary ECs establish a typical vessel network throughout the myocardium, whereas endocardial ECs form a large epithelial sheet with no angiogenic sprouting into the myocardium. Neither coronary arteries, veins, and capillaries, nor lymphatic vessels fuse with the endocardium or open to the heart chamber. The developmental stage during which the specific phenotype of each cardiac EC type is determined remains unclear. The mechanisms involved in EC commitment and diversity can however be more precisely defined by tracking the migratory patterns and lineage decisions of the precursors of cardiac ECs.
DOI	10.1007/s00441-008-0663-z
PMID	18682987