イシイ　ヤスオ   石井　泰雄    所属   統合教育学修センター 統合教育学修センター    職種   講師
論文種別	総説
言語種別	英語
査読の有無	査読あり
表題	Endothelial cell lineages of the heart.
掲載誌名	正式名：Cell and tissue research 略　 称：Cell Tissue Res ISSNコード：(1432-0878)0302-766X(Linking)
掲載区分	国外
巻・号・頁	335(1),pp.67-73
著者・共著者	Ishii Yasuo, Langberg Jonathan, Rosborough Kelley, Mikawa Takashi
発行年月	2009/01
概要	During early gastrulation, vertebrate embryos begin to produce endothelial cells (ECs) from the mesoderm. ECs first form primitive vascular plexus de novo and later differentiate into arterial, venous, capillary, and lymphatic ECs. In the heart, the five distinct EC types (endocardial, coronary arterial, venous, capillary, and lymphatic) have distinct phenotypes. For example, coronary ECs establish a typical vessel network throughout the myocardium, whereas endocardial ECs form a large epithelial sheet with no angiogenic sprouting into the myocardium. Neither coronary arteries, veins, and capillaries, nor lymphatic vessels fuse with the endocardium or open to the heart chamber. The developmental stage during which the specific phenotype of each cardiac EC type is determined remains unclear. The mechanisms involved in EC commitment and diversity can however be more precisely defined by tracking the migratory patterns and lineage decisions of the precursors of cardiac ECs.
DOI	10.1007/s00441-008-0663-z
PMID	18682987