YAMASHITA Shingo
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Assistant Professor |
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Article types | Original article |
Language | English |
Peer review | Non peer reviewed |
Title | Significance of a preoperative tumor marker gradient for predicting microvascular invasion in cases of hepatocellular carcinoma. |
Journal | Formal name:Molecular and clinical oncology Abbreviation:Mol Clin Oncol ISSN code:20499450/20499450 |
Domestic / Foregin | Foregin |
Volume, Issue, Page | 12(3),pp.290-294 |
Author and coauthor | Koizumi Satoshi, Yamashita Shingo, Matsumura Satoshi, Takeda Kazuhisa, Minagawa Takuya, Kobayashi Shinjiro, Hibi Taizo, Shinoda Masahiro, Endo Itaru, Tanabe Minoru, Yamamoto Masakazu, Otsubo Takehito |
Publication date | 2020/03 |
Summary | Although vascular invasion is an important factor in the progression and treatment of hepatocellular carcinoma (HCC), it remains difficult to determine, on the basis of preoperative imaging alone, whether vascular invasion, especially microvascular invasion, has occurred. The current retrospective study enrolled 292 patients who, between 2004 and 2014, underwent curative hepatectomy as an initial treatment for HCC. The patients were divided between those with (n=70) and those without (n=222) microvascular invasion. Whether tumor-marker-based prediction of microvascular invasion was possible was assessed by comparing the preoperative serum α-fetoprotein (AFP) and prothrombin induced by vitamin K absence or antagonist-II concentrations between two groups of patients. The AFP concentration was significantly higher in patients with microvascular invasion compared with patients without microvascular invasion (P=0.0019). Stepwise logistic regression analysis demonstrated the AFP concentration and the logarithmic conversion ratio of the AFP gradient (log AFP grad) to be useful (P=0.0019; 0.0424) for predicting microvascular invasion. The serum AFP concentration and log AFP grad appear to be clinically useful in predicting microvascular invasion in patients with HCC. |
DOI | 10.3892/mco.2020.1975 |
PMID | 32064109 |