マルコ　イチロウ   丸子　一朗    所属   医学部 医学科（東京女子医科大学病院）    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Three-month outcomes of faricimab loading therapy for wet age-related macular degeneration in Japan.
掲載誌名	正式名：Scientific reports 略　 称：Sci Rep ISSNコード：20452322/20452322
掲載区分	国外
巻・号・頁	13(1),pp.8747
著者・共著者	Mukai Ryo, Kataoka Keiko, Tanaka Koji, Miyara Yasunori, Maruko Ichiro, Nakayama Makiko, Watanabe Yuto, Yamamoto Akiko, Wakatsuki Yu, Onoe Hajime, Wakugawa Sorako, Terao Nobuhiro, Hasegawa Taiji, Hashiya Nozomu, Kawai Moeko, Maruko Ruka, Itagaki Kanako, Honjo Jyunichiro, Okada Annabelle A, Mori Ryusaburo, Koizumi Hideki, Iida Tomohiro, Sekiryu Tetsuju
発行年月	2023/05
概要	This multicenter study aimed to assess the short-term effectiveness and safety of faricimab in treatment-naïve patients with wet age-related macular degeneration (wAMD) in Japan. We retrospectively reviewed 63 eyes of 61 patients with wAMD, including types 1, 2, and 3 macular neovascularization as well as polypoidal choroidal vasculopathy (PCV). Patients received three consecutive monthly intravitreal injections of faricimab as loading therapy. Over these 3 months, visual acuity improved gradually compared to baseline. Moreover, the central foveal thickness decreased significantly at 1, 2, and 3 months compared to baseline (p < 0.0001). At 3 months after initiation of faricimab therapy, a dry macula (defined as absence of intraretinal or subretinal fluid) was achieved in 82% of the eyes. Complete regression of polypoidal lesions was observed in 52% of eyes with PCV. Subfoveal choroidal thickness also decreased significantly at 1, 2, and 3 months compared to baseline (p < 0.0001). Although retinal pigment epithelium tears developed in two eyes, there were no other ocular or systemic complications observed during the 3 months of loading therapy. In conclusion, loading therapy using faricimab resulted in improved visual acuity and retinal morphology in Japanese patients with wAMD without particular safety issues.
DOI	10.1038/s41598-023-35759-4
PMID	37253802