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ヤツジ サトル
八辻 賢 所属 医学部 医学科（東京女子医科大学病院） 職種 非常勤講師 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Imaging of nonalcoholic steatohepatitis: advantages and pitfalls of ultrasonography and computed tomography. |
| 掲載誌名 | 正式名：Internal medicine (Tokyo, Japan) 略 称：Intern Med ISSNコード：13497235/09182918 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 48(10),pp.739-46 |
| 著者・共著者 | Tobari Maki, Hashimoto Etsuko, Yatsuji Satoru, Torii Nobuyuki, Shiratori Keiko |
| 発行年月 | 2009/05/15 |
| 概要 | OBJECTIVE:The present study was performed to clarify the ability of ultrasonography (US) and computed tomography (CT) to detect steatosis and advanced fibrosis in nonalcoholic steatohepatitis (NASH) patients, and to assess the influence of steatosis, fibrosis, and obesity on the radiological detection of steatosis and advanced fibrosis.METHODS:One hundred and eighteen biopsy proven NASH patients underwent US and CT within 6 months before or after biopsy. The ability of US and CT to detect histological steatosis and advanced fibrosis was assessed. To evaluate whether fibrosis and obesity interfered with the detection of moderate to severe histological steatosis by US and CT, we analyzed 88 NASH patients with moderate to severe steatosis. To evaluate interference with the detection of advanced fibrosis by steatosis and obesity, we analyzed 59 NASH patients with advanced fibrosis.RESULTS:The sensitivity of US for detecting moderate to severe histological steatosis in patients with mild histological fibrosis was 100%, but this was reduced to 77.8% in patients with advanced histological fibrosis (p=0.001). The sensitivity of CT was 69.8% in patients with mild histological fibrosis and 48.9% in those with advanced histological fibrosis (p=0.047). The sensitivity of US and CT for moderate to severe histological steatosis was similar in each body mass index group. The sensitivity for detecting advanced fibrosis was markedly decreased by severe steatosis and obesity in the case of both US and CT.CONCLUSION:If we are aware of these disadvantages of US and CT, it is useful for diagnosing steatosis and fibrosis in NAFLD patients. |
| DOI | 10.2169/internalmedicine.48.1869 |
| PMID | 19443967 |