カコガワ　ジユン   水主川　純    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	Prolonged fetal bradycardia as the presenting clinical sign in congenital syphilis complicated by necrotizing funisitis: a case report.
掲載誌名	正式名：ISRN obstetrics and gynecology 略　 称：ISRN Obstet Gynecol ISSNコード：20904444/20904436
掲載区分	国外
巻・号・頁	2011,pp.320246
著者・共著者	Kakogawa Jun, Sadatsuki Miyuki, Masuya Norio, Gomibuchi Hideto, Minoura Shigeki, Hoshimoto Kazuhusa
担当区分	筆頭著者,責任著者
発行年月	2011
概要	Syphilis remains a serious cause of neonatal morbidity and mortality worldwide. In this paper, we describe a case of congenital syphilis that was fully supported by abnormal fetal heart rate patterns and placental histopathological evidence. A 24-year-old para 4 woman, who did not attend antenatal care, was admitted to our hospital with a complaint of abdominal discomfort at an estimated 31-week gestation. Fetal heart rate monitoring showed prolonged bradycardia. A neonate weighting 1,423 g with severe birth asphyxia was immediately delivered by cesarean section. Following delivery, the mother and the neonate were diagnosed with syphilis. Histopathological examination confirmed severe chorioamnionitis and necrotizing funisitis with numerous Treponema pallidum. Conclusions. Challenges in establishing the diagnosis of necrotizing funisitis are essential for optimal management of a fetus with a systemic inflammatory response in utero.
DOI	10.5402/2011/320246
PMID	21766037