YUKI ICHIHARA
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Assistant Professor |
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Article types | Original article |
Language | English |
Peer review | Non peer reviewed |
Title | Coronary artery bypass grafting transiently improves myocardial flow reserve in patients with impaired left ventricular function. |
Journal | Formal name:International journal of cardiology Abbreviation:Int J Cardiol ISSN code:18741754/01675273 |
Domestic / Foregin | Foregin |
Volume, Issue, Page | 390,pp.131231 |
Author and coauthor | Nishijima Shuhei†, Nagao Michinobu, Yamamoto Atsushi, Ichihara Yuki, Niinami Hiroshi |
Publication date | 2023/11 |
Summary | BACKGROUND:Myocardial flow reserve (MFR) derived from 13N-ammonia positron emission tomography is an index used to evaluate ischemic cardiomyopathy and predict the prognosis of patients with coronary artery disease (CAD). This study aimed to evaluate the short-term changes in MFR in patients who underwent coronary artery bypass grafting (CABG). In addition, as a reference, we showed the changes in MFR in the percutaneous coronary intervention (PCI) and optimal medical therapy (OMT) patient groups.METHODS:To determine the short-term effects of CABG in CAD with left ventricular dysfunction, myocardial blood flow (MBF) and MFR were measured before and after CABG. Additionally, we showed changes in MBF and MFR of the PCI and OMT patient groups during treatment.RESULTS:We observed that resting MBF did not significantly increase from baseline to post-CABG (0.84 ± 0.32 vs. 0.83 ± 0.23, P = 0.958); however, stress MBF increased significantly from baseline to post-CABG (1.23 ± 0.64 vs. 1.49 ± 0.42, P < 0.001). The global MFR increased significantly from baseline to post-CABG (1.49 ± 0.42 mL/g/min vs. 1.91 ± 0.51 mL/g/min, P < 0.001). Additionally, stress and resting ejection fraction (EF) significantly increased (stress EF: 42 ± 18.7% vs. 50.9 ± 18%, P = 0.005; resting EF: 45.8 ± 19.5% vs. 52.1 ± 19.4%, P = 0.031).CONCLUSIONS:This study demonstrated that CABG significantly improved MFR in a short period of time with left ventricular dysfunction. These findings suggest that epicardial coronary artery patency restores myocardial microcirculatory dysfunction in the short term. |
DOI | 10.1016/j.ijcard.2023.131231 |
PMID | 37536422 |