オオノ ヒデキ
大野 秀樹 所属 医学部 医学科(附属足立医療センター) 職種 講師 |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | INSL5 may be a unique marker of colorectal endocrine cells and neuroendocrine tumors |
掲載誌名 | 正式名:Biochem Biophys Res Commun ISSNコード:1090-2104 (Electronic) 0006-291X (Linking |
掲載区分 | 国外 |
巻・号・頁 | 432,pp.586-592 |
著者・共著者 | Mashima, H Ohno, H Yamada, Y Sakai, T Ohnishi, H |
担当区分 | 2nd著者 |
発行年月 | 2013 |
概要 | Insulin-like peptide 5 (INSL5) is a member of the insulin superfamily, and is a potent agonist for RXFP4. We have shown that INSL5 is expressed in enteroendocrine cells (EECs) along the colorectum with a gradient increase toward the rectum. RXFP4 is ubiquitously expressed along the digestive tract. INSL5-positive EECs have little immunoreactivity to chromogranin A (CgA) and might be a unique marker of colorectal EECs. CgA-positive EECs were distributed normally along the colorectum in INSL5 null mice, suggesting that INSL5 is not required for the development of CgA-positive EECs. Exogenous INSL5 did not affect the proliferation of human colon cancer cell lines, and chemically-induced colitis in INSL5 null mice did not show any significant changes in inflammation or mucosal healing compared to wild-type mice. In contrast, all of the rectal neuroendocrine tumors examined co-expressed INSL5 and RXFP4. INSL5 may be a unique marker of colorectal EECs, and INSL5-RXFP4 signaling might play a role in an autocrine/paracrine fashion in the colorectal epithelium and rectal neuroendocrine tumors. |
DOI | 10.1016/j.bbrc.2013.02.042 |
文献番号 | 23438439 |