オオノ　ヒデキ   大野　秀樹    所属   医学部 医学科（附属足立医療センター）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Receptor for advanced glycation end-products is a marker of type I lung alveolar cells
掲載誌名	正式名：Genes Cells ISSNコード：1356-9597 (Print) 1356-9597 (Linking)
掲載区分	国外
巻・号・頁	9(2),pp.165-74
著者・共著者	Shirasawa, M. Fujiwara, N. Hirabayashi, S. Ohno, H. Iida, J. Makita, K. Hata, Y.
発行年月	2004
概要	Lung alveolar epithelial cells are comprised of type I (ATI) and type II (ATII) cells. ATI cells are polarized, although they have very flat morphology. The identification of marker proteins for apical and basolateral membranes of ATI cells is important to investigate into the differentiation of ATI cells. In this paper, we characterized receptor for advanced glycation end-products (RAGE) as a marker for ATI cells. RAGE was localized on basolateral membranes of ATI cells in the immunoelectron microscopy and its expression was enhanced in a parallel manner to the differentiation of ATI cells in vivo and in primary cultures of ATII cells. RAGE and T1 alpha, a well-known ATI marker protein, were targeted to basolateral and apical membranes, respectively, when expressed in polarized Madine Darby canine kidney cells. Moreover, RAGE was expressed in ATI cells after T1 alpha in vivo and in ex in vivo organ cultures. In conclusion, RAGE is a marker for basolateral membranes of well-differentiated ATI cells. ATI cells require some signal provided by the in vivo environment to express RAGE.
文献番号	15009093