マルコ　ルカ   MARUKO Ruka   丸子　留佳    所属   医学部 医学科（東京女子医科大学病院）    職種   寄附部門助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	EVALUATION OF SHORT-TERM OUTCOMES OF INTRAVITREAL AFLIBERCEPT INJECTIONS FOR AGE-RELATED MACULAR DEGENERATION USING FOCAL MACULAR ELECTRORETINOGRAPHY.
掲載誌名	正式名：Retina (Philadelphia, Pa.) 略　 称：Retina ISSNコード：15392864/0275004X
掲載区分	国外
巻・号・頁	37(3),pp.553-560
著者・共著者	Takayama Kei, Kaneko Hiroki, Ueno Shinji, Maruko Ruka, Piao Chang-Hua, Yasuda Shunsuke, Kawano Kenichi, Ito Yasuki, Terasaki Hiroko
発行年月	2017/03
概要	PURPOSE:To evaluate the relationship between morphological changes and functional improvements assessed using focal macular electroretinograms after intravitreal aflibercept (IVA) injections in eyes with wet age-related macular degeneration.METHODS:The clinical records of 42 eyes of 42 consecutive patients with naive, wet age-related macular degeneration received 3 monthly IVA were reviewed. The best-corrected visual acuity, central foveal thickness, outer retinal thickness, inner retinal thickness at baseline and 1 month after each IVA, and focal macular electroretinograms at baseline and 1 month after the first and third IVA were compared.RESULTS:Best-corrected visual acuity was improved after the third IVA (P = 0.0091). Central foveal thickness and outer retinal thickness showed decreases after every IVA (P < 0.001, respectively). Inner retinal thickness showed a decrease after the second IVA (P = 0.002), after and third IVA (P = 0.001). On focal macular electroretinograms, a- and b-wave amplitudes showed increases after the third IVA (P = 0.0028, P = 0.0012, respectively). Significant correlations were observed between best-corrected visual acuity and central foveal thickness, a-wave amplitude and outer retinal thickness, and b-wave amplitude and inner retinal thickness changes after the third IVA.CONCLUSION:All parameters significantly recovered after three monthly IVA, with a correlation between functional improvements and morphological changes.
DOI	10.1097/IAE.0000000000001225
PMID	27465570