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イシグロ タイチ
石黒 太一 所属 医学部 医学科（附属八千代医療センター） 職種 講師 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection. |
| 掲載誌名 | 正式名：Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 略 称：J Stroke Cerebrovasc Dis ISSNコード：15328511/10523057 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 26(11),pp.2587-2594 |
| 著者・共著者 | Ono Hirohisa, Nishijima Yoji, Ohta Shigeo, Sakamoto Masaki, Kinone Kazunori, Horikosi Tohru, Tamaki Mituyuki, Takeshita Hirosi, Futatuki Tomoko, Ohishi Wataru, Ishiguro Taichi, Okamoto Saori, Ishii Shou, Takanami Hiroko |
| 発行年月 | 2017/11 |
| 概要 | BACKGROUND:Molecular hydrogen (H2) acts as a therapeutic antioxidant. Inhalation of H2 gas (1-4%) was effective for the improvement of cerebral infarction in multiple animal experiments. Thus, for actual applications, a randomized controlled clinical study is desired to evaluate the effects of inhalation of H2 gas. Here, we evaluate the H2 treatment on acute cerebral infarction.METHODS:Through this randomized controlled clinical study, we assessed the safety and effectiveness of H2 treatment in patients with cerebral infarction in an acute stage with mild- to moderate-severity National Institute of Health Stroke Scale (NIHSS) scores (NIHSS = 2-6). We enrolled 50 patients (25 each in the H2 group and the control group) with a therapeutic time window of 6 to 24 hours. The H2 group inhaled 3% H2 gas (1 hour twice a day), and the control group received conventional intravenous medications for the initial 7 days. The evaluations included daily vital signs, NIHSS scores, physical therapy indices, weekly blood chemistry, and brain magnetic resonance imaging (MRI) scans over the 2-week study period.RESULTS:The H2 group showed no significant adverse effects with improvements in oxygen saturation. The following significant effects were found: the relative signal intensity of MRI, which indicated the severity of the infarction site, NIHSS scores for clinically quantifying stroke severity, and physical therapy evaluation, as judged by the Barthel Index.CONCLUSIONS:H2 treatment was safe and effective in patients with acute cerebral infarction. These results suggested a potential for widespread and general application of H2 gas. |
| DOI | 10.1016/j.jstrokecerebrovasdis.2017.06.012 |
| PMID | 28669654 |