YOSHIDA Keita    Department   School of Medicine, School of Medicine    Position   Assistant Professor
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Nonreproductive role of gonadotropin-releasing hormone in the control of ascidian metamorphosis.
Journal	Formal name：Developmental dynamics : an official publication of the American Association of Anatomists Abbreviation：Dev Dyn ISSN code：1097-0177(Electronic)1058-8388(Linking)
Domestic / Foregin	Foregin
Volume, Issue, Page	243(12),pp.1524-35
Author and coauthor	Kamiya Chisato†, Ohta Naoyuki, Ogura Yosuke, Yoshida Keita, Horie Takeo, Kusakabe Takehiro G, Satake Honoo, Sasakura Yasunori*
Publication date	2014/12
Summary	BACKGROUND:Gonadotropin-releasing hormones (GnRHs) are neuropeptides that play central roles in the reproduction of vertebrates. In the ascidian Ciona intestinalis, GnRHs and their receptors are expressed in the nervous systems at the larval stage, when animals are not yet capable of reproduction, suggesting that the hormones have non-reproductive roles.RESULTS:We showed that GnRHs in Ciona are involved in the animal's metamorphosis by regulating tail absorption and adult organ growth. Absorption of the larval tail and growth of the adult organs are two major events in the metamorphosis of ascidians. When larvae were treated with GnRHs, they completed tail absorption more frequently than control larvae. cAMP was suggested to be a second messenger for the induction of tail absorption by GnRHs. tGnRH-3 and tGnRH-5 (theRESULTS:"RESULTS:tRESULTS:"RESULTS:indicatesRESULTS:"RESULTS:tunicateRESULTS:"RESULTS:) inhibited the growth of adult organs by arresting cell cycle progression in parallel with the promotion of tail absorption.CONCLUSIONS:This study provides new insights into the molecular mechanisms of ascidian metamorphosis conducted by non-reproductive GnRHs.
DOI	02/dvdy.24176
Document No.	25130398