イイヅカ　ユズル   飯塚　讓    所属   医学部 医学科    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Impact of discontinuation of fish oil after pioglitazone-fish oil combination therapy in diabetic KK mice.
掲載誌名	正式名：The Journal of nutritional biochemistry 略　 称：J Nutr Biochem ISSNコード：18734847/09552863
掲載区分	国外
巻・号・頁	76,pp.108265
著者・共著者	Iizuka Yuzuru, Chiba Kanako, Kim Hyounju, Hirako Satoshi, Wada Masahiro, Matsumoto Akiyo
担当区分	筆頭著者
発行年月	2020/02
概要	Pioglitazone is one of the thiazolidinediones (TZDs) and an insulin-sensitive drug for type 2 diabetes. In our previous study, a combination of pioglitazone and fish oil rich in n-3 polyunsaturated fatty acids (PUFAs) was shown to inhibit pioglitazone-induced side effects, such as accumulation of subcutaneous fat and body weight gain. However, the effects of the discontinuation of fish oil after combination treatment with TZD and fish oil are not clear. In this study, discontinuation of fish oil for 4 weeks showed several unfavorable effects: (1) return of plasma adiponectin level, (2) reversal of the inhibition of lipogenesis and activation of fatty acid β-oxidation in liver, (3) increase in hypertrophic adipocytes in epidydimal white adipose tissue (WAT) and (4) accumulation of lipids in brown adipose tissue (BAT). However, insulin resistance was ameliorated by pioglitazone with or without fish oil treatment and the discontinuation of fish oil. These findings indicate that discontinuation of n-3 PUFA after combination therapy with TZDs adversely affects lipid metabolism and energy homeostasis in liver, epididymal WAT and BAT.
DOI	10.1016/j.jnutbio.2019.108265
PMID	31760227