イズハラ　ルナ   Luna Izuhara   伊豆原　るな    所属   医学部 医学科    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Regulation of aging by balancing mitochondrial function and antioxidant levels
掲載誌名	正式名：The Journal of Physiological Sciences ISSNコード：1880-6562
掲載区分	国外
出版社	Springer Japan
巻・号・頁	72(28),pp.https://doi.org/10.1186/s12576-022-00853-1
著者・共著者	Yoshina Sawako†, Izuhara Luna, Kamatani Naoyuki, Mitani Shohei
担当区分	2nd著者
発行年月	2022/11/15
概要	Aging is the deterioration of physiological mechanisms that is associated with getting old. There is a link between aging and mitochondrial function. However, there is an unresolved relationship between ATP levels and aging. To address this issue, we administered febuxostat (FBX), an inhibitor of human xanthine oxidase (XO)/xanthine dehydrogenase (XDH), to C. elegans. We used C. elegans as a model to evaluate the effects of FBX and to challenge the enigma of the relationship between ATP and lifespan. In this study, we showed that FBX protects mitochondria and prevents age-related muscle deterioration in C. elegans. In addition, we showed that FBX administration could increase ATP levels without overloading the mitochondria while extending the lifespan. We also showed that the combination of FBX and an antioxidant as a protection against ROS prolongs lifespan more. We have shown that the antioxidant effects and increased ATP levels may lead to antiaging effects.
DOI	https://doi.org/10.1186/s12576-022-00853-1