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ホシノ ジユンイチ
HOSHINO Junichi
星野 純一 所属 医学部 医学科（東京女子医科大学病院） 職種 教授・基幹分野長 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | テリパラチド治療後の低ホスファターゼ血症関連骨粗鬆症の骨組織形態学的解析(A Bone Histomorphometric Analysis of Hypophosphatasia-related Osteoporosis after Teriparatide Treatment) |
| 掲載誌名 | 正式名：Internal medicine 略 称：Intern Med ISSNコード：09182918/13497235 |
| 掲載区分 | 国外 |
| 出版社 | (一社)日本内科学会 |
| 巻・号・頁 | 62(1),pp.75-79 |
| 著者・共著者 | Mizuno Hiroki, Sawa Naoki, Sekine Akinari, Inoue Noriko, Oba Yuki, Ikuma Daisuke, Yamanouchi Masayuki, Hasegawa Eiko, Suwabe Tatsuya, Suzuki Hisanori, Hoshino Junichi, Ubara Yoshifumi |
| 発行年月 | 2023/01/01 |
| 概要 | A 79-year-old man was admitted with a compression fracture of the first lumbar vertebra. His alkaline phosphatase (ALP) level was 35 IU/L, and his dual energy X-ray absorptiometry T score was -3.7 standard deviations, indicating osteoporosis. A genetic analysis showed a mutation of the alkaline phosphatase biomineralization-associated gene encoding tissue-nonspecific alkaline phosphatase. Hypophosphatasia-related osteoporosis was diagnosed. Alendronate, teriparatide, and minodronate were administered in that order. The ALP level increased during teriparatide use. A bone biopsy performed after three years of teriparatide treatment showed that cancellous bone was adynamic. In cortical bone, tetracycline double-labeling indicates enhanced bone formation. Teriparatide may thus be a viable treatment option even in patients with hypophosphatasia. |
| DOI | 10.2169/internalmedicine.9624-22 |
| 文献番号 | 2024036556 |
| PMID | 35650135 |