オガサワラ　トシエ   OGASAWARA Toshie   小笠原　壽恵    所属   医学部 医学科（附属足立医療センター）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	JAK2-negative acute monocytic leukemia with TET2 mutation in essential thrombocythemia with JAK2 mutation with literature review
掲載誌名	正式名：Leukemia Ressarch Reports
掲載区分	国外
巻・号・頁	pp.1
著者・共著者	Toshie Ogasawara, Kiyotaka Kawauchi, Takuya Ono, Shoko Marshall, Kotaro Shide, Kazuya Shimoda, Naoki Mori,Hiroshi Sakura
発行年月	2020/01/16
概要	Essential thrombocythemia (ET) is an indolent myeloproliferative neoplasm (MPN) with a transformation to acute myeloid leukemia in <5% of patients. A 79-year-old man with JAK2V617F-positive ET exhibited leukocytosis with an increase in monoblastic cells, leading to a diagnosis of acute monoblastic and monocytic leukemia. Leukemic cells carried a TET2 mutation but not JAK2V617F mutation. We concluded that the TET2 mutation occurred in MPN-initiating cells and overcame JAK2-mutated cells. The absence of a JAK2 mutation in the leukemic cells in this case suggests the leukemia emerged from a JAK2-negative MPN cell clone carrying the TET2 mutation.
DOI	doi.org/10.1016/j.lrr.2019.100194